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99 Cards in this Set

  • Front
  • Back
Pulmonary fibrosis
bleomycin, amiodarone, busulfan
Hepatitis
Isoniazid, halothane
Hepatic necrosis
Halothane, valproic acid, acetaminophen, Amanita phalloides
Anaphylaxis
Penicillin
SLE-like syndrome
Hydralazine, INH, procainamide, phenytoin
Hemolysis in G6PD deficient patients
Sulfonamides, INH, aspirin, ibuprofen, primaquine, pyrimethamine, chloramphenicol
Thrombotic complications
Oral contraceptives
Adrenocortical insufficiency
withdrawal of glucocorticoids
Photosensitivity
Sulfonamides, amiodarone, tetracycline
Tubulointerstitial nephritis
Sulfonamides, furosemide, methicillin, rifampin, NSAIDs (except aspirin)
Hot flashes
Tamoxifen
Cutaneous flushing
Niacin, calcium channel blockers, adenosine, vancomycin
Cardiac toxicity
doxorubicin (Adriamycin), daunorubicin
Agranulocytosis
Clozapine, carbamazepine, colchicine
Stevens-Johnson syndrome
Ethosuximide, sulfonamides
Cinchonism
quinidine, quinine
Tendonitis, tendon rupture; cartilage damage in kids
Fluoroquinolones
Disulfiram-like reaction
Metronidazole, certain cephalosporins, procarbazine, sulfonylureas
Ototoxicity and nephrotoxicity
Vancomycin, aminoglycosides, loop diuretics, cisplatin
Drug-induced parkinsonism
Haloperidol, chlorpromazine, reserpine, MPTP
Torsades de pointes
Class III (sotalol) and class IA (quinidine) antiarrhythmics
Aplastic anemia
chloramphenicol, benzene, NSAIDs
Neuro/nephrotoxicity
Polymyxins
Pseudomembranous colitis
Clindamycin, ampicillin
Gynecomastia
Spironolactone, digitalis, cimetidine, alcohol, estrogens, ketoconazole
Atropine-like side effects
TCAs
Cough
ACE inhibitors (via bradykinin)
Gingival hyperplasia
Phenytoin
Diabetes insipidus
Lithium
Tardive dyskinesia
Antipsychotics
Fanconi's syndrome
expired tetracyclines
Gray baby syndrome
Chloramphenicol
Red-man syndrome
Vancomycin
Lactic acidosis
Metformin, NRTIs
Lipodystrophy
Protease inhibitors
Extrapyramidal side effects
chlorpromazine, thioridazine, haloperidol
Osteoporosis
Corticosteroids, heparin
Coronary vasospasm
Cocaine
Inducers of P450
quinidine, barbiturates, phenytoin, rifampin, griseofulvin, carbamazepine
Inhibitors of P450
isoniazid, sulfonamides, cimetidine, ketoconazole, erythromycin, grapefruit juice
Antidote for acetaminophen toxicity
N-acetylcysteine
Tx for salicylate poisoning
Alkalinize urine, dialysis
Antidote for organophosphage (anticholinesterase) poisoning
Atropine, pralidoxime
Antidote for antimuscarinic/anticholinergic agent poisoning
physostigmine salicylate
Antidote for beta-blocker poisoning
glucagon
Antidote for digitalis toxicity
stop dig, normalize K+, lidocaine, anti-dig Fab fragments, Mg2+
Antidote for iron poisoning
deferoxamine
Antidote for lead poisoning
CaEDTA, dimercaprol, succimer, penicillamine
Antidote for arsenic, mercury or gold poisoning
dimercaprol, succimer
Antidote for copper, arsenic or gold poisoning
penicillamine
Antidote for cyanide poisoning
nitrite, hydroxocobalamin, thiosulfate
Antidote for methemoglobin poisoning
methylene blue
Antidote for CO poisoning
100% O2, hyperbaric O2
Antidote for methanol or ethylene glycol poisoning
Ethanol, dialysis, fomepizole
Antidote for opioid overdose
Naloxone/naltrexone
Antidote for benzodiazepine overdose
Flumazenil
Antidote for TCA overdose
NaHCO3 (nonspecific)
Antidote for heparin overdose
protamine
Antidote for warfarin overdose
vitamin K, fresh frozen plasma
Antidote for tPA, streptokinase overdose
Aminocaproic acid
Hemorrhagic cystitis
Cyclophosphamide (tx with mesna)
Leucovorin rescue
Methotrexate
Nephrotoxicity preventable with mannitol diuresis
Cyclosporine
Risk of life-threatening hypotension in patients taking nitrates
Sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)
Stimulation of ovulation
Clomiphene
Progesterone receptor antagonist
mifepristone (RU-486)
Stimulates relase of endogenous insulin (insulin secretagogues)
Sulfonylureas (glyburide, glipizide); repaglinide, nateglinide
Inhibits gluconeogenesis, increases glycolysis
Metformin
Increases target cell response to insulin
Pioglitazone, rosiglitazone
Inhibits glucose absorption (alpha-glucosidase inhibitors)
Acarbose, miglitol
Pulsatile leuprolide is used to treat?
Infertility (agonist activity)
Continuous leuprolide is used to treat?
Prostate cancer (antagonist activity)
Hyperthyroidism
Propylthiouracil, methimazole
Tx of BPH, male pattern baldness
5-alpha-reductase inhibitor (finasteride)
Nonsteroidal testosterone receptor antagonist
Flutamide (used in prostate cancer)
Iatrogenic Cushing's syndrome
Glucocorticoids (hydrocortisone, prednisone, dexamethasone, beclomethasone)
Anti-GP IIb/IIIa (antiplatelet)
Abciximab (most potent antiplatelet drug; used in acute coronary syndrome, PTCA)
Inhibitor of fibrinolysis
Aminocaproic acid
Irreversible COX-1 and -2 inhibitor
Aspirin
Toxicity includes Reye's syndrome, tinnitus, gastric ulceration
Aspirin
Irreversible ADP receptor antagonist
Clopidogrel
PGE1 analog; abortifacient, ulcer prevention, maintenance of patent ductus arteriosus
Misoprostol
Used to treat Crohn's disease, rheumatoid arthritis
Infliximab (antibody to TNF-alpha)
Used to treat ulcerative colitis, Crohn's disease
Sulfasalazine
Serotonin antagonist; powerful central-acting antiemetic
Ondansetron
Non-specific beta-agonist
Isoproterenol
Beta-2 agonists
Albuterol (acute exacerbation), salmeterol (prophylaxis)
Phosphodiesterase inhibitor --> causes bronchodilation
Theophylline
Muscarinic antagonist for prevention of bronchoconstriction
Ipratroprium
Prevents mast cell degranulation (prophylactic only)
Cromolyn sodium
First-line therapy for chronic asthma
Corticosteroids (beclomethasone, prednisone) --> inhibit synthesis of all cytokines, inactivate NF-kB
Leukotriene receptor antagonists
Zafirlukast, montelukast
Lipoxygenase inhibitor
Zileuton
Prevents ACh release from vesicles
Botulinum
Inhibits vesicular monoamine transporter (VMAT)
Reserpine
Cholinomimetic (direct agonist) for urinary retention
Bethanechol
Direct ACh agonist for glaucoma
Carbachol, pilocarpine
Diagnosis of myasthenia gravis
edrophonium
Used to treat atropine overdose
physostigmine