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99 Cards in this Set
- Front
- Back
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Pulmonary fibrosis
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bleomycin, amiodarone, busulfan
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Hepatitis
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Isoniazid, halothane
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Hepatic necrosis
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Halothane, valproic acid, acetaminophen, Amanita phalloides
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Anaphylaxis
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Penicillin
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SLE-like syndrome
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Hydralazine, INH, procainamide, phenytoin
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Hemolysis in G6PD deficient patients
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Sulfonamides, INH, aspirin, ibuprofen, primaquine, pyrimethamine, chloramphenicol
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Thrombotic complications
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Oral contraceptives
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Adrenocortical insufficiency
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withdrawal of glucocorticoids
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Photosensitivity
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Sulfonamides, amiodarone, tetracycline
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Tubulointerstitial nephritis
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Sulfonamides, furosemide, methicillin, rifampin, NSAIDs (except aspirin)
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Hot flashes
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Tamoxifen
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Cutaneous flushing
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Niacin, calcium channel blockers, adenosine, vancomycin
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Cardiac toxicity
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doxorubicin (Adriamycin), daunorubicin
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Agranulocytosis
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Clozapine, carbamazepine, colchicine
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Stevens-Johnson syndrome
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Ethosuximide, sulfonamides
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Cinchonism
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quinidine, quinine
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Tendonitis, tendon rupture; cartilage damage in kids
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Fluoroquinolones
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Disulfiram-like reaction
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Metronidazole, certain cephalosporins, procarbazine, sulfonylureas
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Ototoxicity and nephrotoxicity
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Vancomycin, aminoglycosides, loop diuretics, cisplatin
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Drug-induced parkinsonism
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Haloperidol, chlorpromazine, reserpine, MPTP
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Torsades de pointes
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Class III (sotalol) and class IA (quinidine) antiarrhythmics
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Aplastic anemia
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chloramphenicol, benzene, NSAIDs
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Neuro/nephrotoxicity
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Polymyxins
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Pseudomembranous colitis
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Clindamycin, ampicillin
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Gynecomastia
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Spironolactone, digitalis, cimetidine, alcohol, estrogens, ketoconazole
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Atropine-like side effects
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TCAs
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Cough
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ACE inhibitors (via bradykinin)
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Gingival hyperplasia
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Phenytoin
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Diabetes insipidus
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Lithium
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Tardive dyskinesia
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Antipsychotics
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Fanconi's syndrome
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expired tetracyclines
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Gray baby syndrome
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Chloramphenicol
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Red-man syndrome
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Vancomycin
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Lactic acidosis
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Metformin, NRTIs
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Lipodystrophy
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Protease inhibitors
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Extrapyramidal side effects
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chlorpromazine, thioridazine, haloperidol
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Osteoporosis
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Corticosteroids, heparin
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Coronary vasospasm
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Cocaine
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Inducers of P450
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quinidine, barbiturates, phenytoin, rifampin, griseofulvin, carbamazepine
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Inhibitors of P450
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isoniazid, sulfonamides, cimetidine, ketoconazole, erythromycin, grapefruit juice
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Antidote for acetaminophen toxicity
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N-acetylcysteine
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Tx for salicylate poisoning
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Alkalinize urine, dialysis
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Antidote for organophosphage (anticholinesterase) poisoning
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Atropine, pralidoxime
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Antidote for antimuscarinic/anticholinergic agent poisoning
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physostigmine salicylate
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Antidote for beta-blocker poisoning
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glucagon
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Antidote for digitalis toxicity
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stop dig, normalize K+, lidocaine, anti-dig Fab fragments, Mg2+
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Antidote for iron poisoning
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deferoxamine
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Antidote for lead poisoning
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CaEDTA, dimercaprol, succimer, penicillamine
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Antidote for arsenic, mercury or gold poisoning
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dimercaprol, succimer
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Antidote for copper, arsenic or gold poisoning
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penicillamine
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Antidote for cyanide poisoning
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nitrite, hydroxocobalamin, thiosulfate
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Antidote for methemoglobin poisoning
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methylene blue
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Antidote for CO poisoning
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100% O2, hyperbaric O2
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Antidote for methanol or ethylene glycol poisoning
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Ethanol, dialysis, fomepizole
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Antidote for opioid overdose
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Naloxone/naltrexone
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Antidote for benzodiazepine overdose
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Flumazenil
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Antidote for TCA overdose
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NaHCO3 (nonspecific)
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Antidote for heparin overdose
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protamine
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Antidote for warfarin overdose
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vitamin K, fresh frozen plasma
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Antidote for tPA, streptokinase overdose
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Aminocaproic acid
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Hemorrhagic cystitis
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Cyclophosphamide (tx with mesna)
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Leucovorin rescue
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Methotrexate
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Nephrotoxicity preventable with mannitol diuresis
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Cyclosporine
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Risk of life-threatening hypotension in patients taking nitrates
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Sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)
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Stimulation of ovulation
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Clomiphene
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Progesterone receptor antagonist
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mifepristone (RU-486)
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Stimulates relase of endogenous insulin (insulin secretagogues)
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Sulfonylureas (glyburide, glipizide); repaglinide, nateglinide
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Inhibits gluconeogenesis, increases glycolysis
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Metformin
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Increases target cell response to insulin
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Pioglitazone, rosiglitazone
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Inhibits glucose absorption (alpha-glucosidase inhibitors)
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Acarbose, miglitol
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Pulsatile leuprolide is used to treat?
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Infertility (agonist activity)
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Continuous leuprolide is used to treat?
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Prostate cancer (antagonist activity)
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Hyperthyroidism
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Propylthiouracil, methimazole
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Tx of BPH, male pattern baldness
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5-alpha-reductase inhibitor (finasteride)
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Nonsteroidal testosterone receptor antagonist
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Flutamide (used in prostate cancer)
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Iatrogenic Cushing's syndrome
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Glucocorticoids (hydrocortisone, prednisone, dexamethasone, beclomethasone)
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Anti-GP IIb/IIIa (antiplatelet)
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Abciximab (most potent antiplatelet drug; used in acute coronary syndrome, PTCA)
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Inhibitor of fibrinolysis
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Aminocaproic acid
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Irreversible COX-1 and -2 inhibitor
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Aspirin
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Toxicity includes Reye's syndrome, tinnitus, gastric ulceration
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Aspirin
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Irreversible ADP receptor antagonist
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Clopidogrel
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PGE1 analog; abortifacient, ulcer prevention, maintenance of patent ductus arteriosus
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Misoprostol
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Used to treat Crohn's disease, rheumatoid arthritis
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Infliximab (antibody to TNF-alpha)
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Used to treat ulcerative colitis, Crohn's disease
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Sulfasalazine
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Serotonin antagonist; powerful central-acting antiemetic
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Ondansetron
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Non-specific beta-agonist
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Isoproterenol
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Beta-2 agonists
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Albuterol (acute exacerbation), salmeterol (prophylaxis)
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Phosphodiesterase inhibitor --> causes bronchodilation
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Theophylline
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Muscarinic antagonist for prevention of bronchoconstriction
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Ipratroprium
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Prevents mast cell degranulation (prophylactic only)
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Cromolyn sodium
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First-line therapy for chronic asthma
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Corticosteroids (beclomethasone, prednisone) --> inhibit synthesis of all cytokines, inactivate NF-kB
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Leukotriene receptor antagonists
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Zafirlukast, montelukast
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Lipoxygenase inhibitor
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Zileuton
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Prevents ACh release from vesicles
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Botulinum
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Inhibits vesicular monoamine transporter (VMAT)
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Reserpine
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Cholinomimetic (direct agonist) for urinary retention
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Bethanechol
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Direct ACh agonist for glaucoma
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Carbachol, pilocarpine
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Diagnosis of myasthenia gravis
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edrophonium
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Used to treat atropine overdose
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physostigmine
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