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11 Cards in this Set
- Front
- Back
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metopirone
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inhibits 11 beta hydroxylase, cushings
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ketoconazole
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inhibits 11 beta hydroxylase, cushings
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trilostane
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inhibits 3 beta hydroxyteroid dehydrogenase; pregnolone to progesterone; cushings
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aminoglutethimide
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inhibits cholesterol desmolase; cholesterol to prenolone; congenital hyperplasia
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fludrocortisone
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potent mineral and gluco, use with cortisol in addisons
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beclomethasone
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surfactant
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chronic glucocorticoids
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osteoporosis, glaucoma, peptic ulcer, myopathy, HT, prolonged wound healing, mask infection
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glucocorticoids in order of highest to lowest glucocorticoid
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dexamethasone, betamethasone, triamcinolone, methylprednisolone, predinose
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mineralcorticoids in order of highest to lowest mineralcorticoid activity
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aldosterone, fludrocortisone, deoxycorticosterone, hydrocotisone (cortisol), cortisone
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glucocorticoid effects
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catabolic, inhibit leukocyte migration, inhibit release of vasoactive, decrease phospholipase A2, decrease capillary perm, increase vasoconstrict, decrease lympho, eoso, baso, increase neutrophils and thrombocytes, euphoria and seizures, inhibit fibrin deposition, decrease Vit D action, produce acid and pepsin, produce surfactant, decrease protein synth in lymphoid tissues
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alternate day
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use intermediate steroids, minimizes Ses
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