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11 Cards in this Set

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metopirone
inhibits 11 beta hydroxylase, cushings
ketoconazole
inhibits 11 beta hydroxylase, cushings
trilostane
inhibits 3 beta hydroxyteroid dehydrogenase; pregnolone to progesterone; cushings
aminoglutethimide
inhibits cholesterol desmolase; cholesterol to prenolone; congenital hyperplasia
fludrocortisone
potent mineral and gluco, use with cortisol in addisons
beclomethasone
surfactant
chronic glucocorticoids
osteoporosis, glaucoma, peptic ulcer, myopathy, HT, prolonged wound healing, mask infection
glucocorticoids in order of highest to lowest glucocorticoid
dexamethasone, betamethasone, triamcinolone, methylprednisolone, predinose
mineralcorticoids in order of highest to lowest mineralcorticoid activity
aldosterone, fludrocortisone, deoxycorticosterone, hydrocotisone (cortisol), cortisone
glucocorticoid effects
catabolic, inhibit leukocyte migration, inhibit release of vasoactive, decrease phospholipase A2, decrease capillary perm, increase vasoconstrict, decrease lympho, eoso, baso, increase neutrophils and thrombocytes, euphoria and seizures, inhibit fibrin deposition, decrease Vit D action, produce acid and pepsin, produce surfactant, decrease protein synth in lymphoid tissues
alternate day
use intermediate steroids, minimizes Ses