Pharm - Gi Acid Suppresion, Gi Protectants, Anti-Inflammatories

Front 1

Parietal cell release of protons into stomach are enhanced by?

Back 1

-gastrin
-histamine
-acetylcholine

Front 2

Proton release into the the stomach from parietal cells is controlled by?

Back 2

H+/K+ ATPase

Front 3

Most effective drugs to raise stomach pH

Back 3

-Famotidine
-Omeprazole

Front 4

Antacids
-mechanism of action

Back 4

-neutralize stomach acids by forming water and neutral salts
-absorb bile salts
-stimulate PGE synthesis
-dec. pepsin

Front 5

Antacid
-duration of effect

Back 5

-short

Front 6

Antacids
-Drug interaction

Back 6

Dec. absorption of:
-fluoroquinolones
-tetracyclines
-domperidone
-digoxin

Front 7

Antacid
-Drugs/Formulations

Back 7

-aluminum hydroxide
-magnesium hydroxide
-calcium carbonate

Front 8

Sucralfate
-Mechanism of action

Back 8

-dissociation into sucrose sulfate and aluminum hydroxide (antacid)

Front 9

Sucrose sulfate effect

Back 9

Helps to heal ulcers
-inactivate pepsin
-absorb bile acid
-Inc. PGE synthesis
-Inc. epidermal growth factor

Front 10

Sucralfate
-adverse effects

Back 10

-constipation

Front 11

Sucralfate
-drug interactions

Back 11

Decrease absorption of:
-fluoroquinolones
-tetracyclines
-digoxin

Front 12

Histamine antagonist
-mechanism of action

Back 12

-H2 antagonist
-decreases acid secretion

Front 13

Histamine antagonist
-drugs

Back 13

-Cimetidine
-Ranitidine
-Famotidine

Front 14

Most widely used histamine antagonist for acid suppression

Back 14

-famotidine

Front 15

Famotidine
-animals used for

Back 15

dogs and cats

Front 16

Famotidine
-potency

Back 16

-long

Front 17

Proton Pump Inhibitors
-mechanism of action

Back 17

-irreversibly inhibit H+/K+ ATPase

Front 18

Proton Pump Inhibitors
-drugs

Back 18

Omeprazole

Front 19

Omeprazole
-use

Back 19

Prevent NSAID ulcers

Front 20

Omeprazole
-onset of action

Back 20

-quick

Front 21

Omeprazole
-route of elimination

Back 21

hepatic metabolism

Front 22

Omeprazole
-adverse effects

Back 22

-diarrhea
-bacterial overgrowth

Front 23

Omeprazole
-Drug interactions

Back 23

Decreased absorption of:
-Ketoconazole
-Itraconazole
-Domperidone

Front 24

NSAID Ulcer Prevention
-drugs

Back 24

Misoprostol

Front 25

Misoprostol
-mechanism of action

Back 25

-synthetic prostaglandin

Front 26

Misoprostol
-effects

Back 26

-dec. acidity
-inc. mucous secretion
-inc. bicarbonate secretion
-inc. mucosal blood flow

Front 27

Misoprostol
-route of elimination

Back 27

-hepatic metabolism

Front 28

Misoprostol
-adverse effects

Back 28

-diarrhea
-cramps
-abortion

Front 29

Misoprostol
-dosing

Back 29

3-4x/day

Front 30

Metronidazole
-mechanism of action

Back 30

-antimicrobial
-alters GIT flora

Front 31

Metronidazole
-indication for use

Back 31

colitis

Front 32

Metronidazole
-route of elimination

Back 32

-hepatic metabolism

Front 33

Metronidazole
-adverse effects

Back 33

toxicity
-tremors (GABA inhibition)

Front 34

Bismuth Subsalicylate
-mechanism of action

Back 34

-salicylate is anti-inflammatory
-absorbs bacterial enterotoxins
-creates a gastric and intestinal protective effect

Front 35

Bismuth Subsalicylate
-adverse effects

Back 35

-NSAID induced GI toxicity
-Salicylate toxicity
-Longer bleeding times
-discolored stool

Front 36

Immune system drugs

Back 36

-corticosteroids
-sulfasalazine

Front 37

Sulfasalazine
-mechanism of action

Back 37

Anti-inflammatory
-LOX inhibition
-Inhibition of TNF-alpha, IL-1, NF-kB, oxygen free radicals

Front 38

Sulfasalazine
-indication for use

Back 38

-colitis

Front 39

Sulfasalazine
-adverse effects

Back 39

-dry eye
-hypersensitivity
-hepatotoxicosis

Front 40

Sulfasalazine
-animal to use cautiously with

Back 40

-cats