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15 Cards in this Set
- Front
- Back
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Cimetidine
Ranitidine Famotidine Nizatidine |
Reversible H2R antagonists
Use: ulcer, gastritis, mild GERD tox: cimetidine is P-450 inhibitor, antiandrogen, can cross blood-brain barrier/placenta (confusion/dizziness/HA). Cimetidine and ranitidine decrease renal Cr excretion |
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Omeprazole
Lansoprazole |
PPI (irreversible H/K-ATPase inhibition of parietal cells)
use: ulcer, gastritis, GERD, Zollinger-Ellison |
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Bismuth
Sucralfate |
physically protect ulcer base and allow bicarb secretion to reestablish pH in mucus layers.
use: ulcers healing, traveler's diarrhea |
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H. Pylori ulcer tx
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triple therapy:
metronidazole amoxicillin (tetracycline) bismuth +/- PPI |
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Misoprostol
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PGE1 analogue. increases mucus barrier and decreases acid production.
use: NSAID-induced ulcers; PDA maintenance; induce labor tox: diarrhea, abortifacient |
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Pirenzepine
Propantheline |
Muscarinic antagonist for M1 (ECL cells, histamine) and M3 (parietal cells, H).
use: ulcer tox: tachycardia, dry mouth, difficulty focusing eyes |
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Aluminum hydroxide
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antacid
tox: constipation, hypophosph, proximal m. weakness, osteodystrophy, seizures, hypokalemia |
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Mg. hydroxide
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antacid
tox: diarrhea, hyporeflexia, hypotension, cardiac arrest, hypokalemia |
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Ca. carbonate
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hypercalcemia, rebound acid increase, hypokalemia
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Antacids can affect other drugs
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chelation and decreased effectiveness of ciprofloxacin, tetracycline
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Infliximab
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monoclonal TNF-Ab
use: Crohn's, RA tox: respiratory infection, fever, hypotension |
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Sulfasalazine
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sulfapyridine (antibx) + mesalamine (anti-inflamm.)
activated by colonic bacteria use: IBD (UC, Crohn's) tox: malaise, nausea, sulfonamide toxicity, reversible oligospermia |
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Ondansetron
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5-HT3 antagonist
tox: HA, constipation |
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Metoclopramide (Reglan)
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D2 receptor antagonist (increases resting tone, contractility, LES tone, motility)
use: gastroparesis tox: parkinsonian, restlessness, drowsy, fatigue, depression, nausea, diarrhea interacts: digoxin, diabetic agents contraind: SBO! |
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Meclizine
Dimenhydrinate Scopolamine |
motion sickness
scopolamine: anti-muscarinic Meclizine/Dimenhydr: anti-muscarinic, anti-histaminic tox: blurry vision, dry mouth, palpitations, urinary retention, constipation |
