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24 Cards in this Set

  • Front
  • Back
Name the types of dementia
Vascular– CAD long term
Dementia with Lewy bodies (Parkinson like)
Frontotemporal-(most deleriums attributed to this area)
What are the hallmarks of dementia?
Amyloid-beta(Aβ or Abeta)
Neurofibrillary tangles
Neuronal degeneration
What are the signs/symptoms of dementia?
Decline in activities of daily living
Changes in personality
Increase in resource utilization
e.g. Ask people to do you favors more than usual
Name some meds that can cause ALOC
Antibiotics(e.g. Fluoroquinolones – causes CNS effects – altered mental status)
Antihypertensives(e.g. Propanolol – crosses the blood brain barrier (BBB))
Anti-manics(Thorazine, Olanzapine – atypical and typical anti-psychotics)
Anti-histamines(cause sedation, anti-cholinergic like effects)
H2 antagonist
Muscle relaxants(Flexeril, Cyclobenzapine)
NSAIDS(can cause renal toxicity)
What would you look for in a CBC on a pt with ALOC
Check if infection(Meningitis etc…)
Electrolytes(hyper/hyponatremia etc…)
Glucose (hypoglycemic)
BUN/SCr ratio (can tell us if we are dehydrated)
If ratio is greater than 20, we can be dehydrated
Why are LFTs important to check in a pt with ALOC?
Hepatic encephalopathy
T/F Folic acid toxicity can cause dementia
FALSE: Folic acid deficiency causes dementia
What agents are used to Tx dementia?
What is the MOA of Tacrine (Cognex)?
Cholinesterase inhibitor; Elevates ACH in cerebral cortex by slowing the degradation of ACH
What is the drug interactions of Tacrine?
Which drug is hardly ever used anymore due to LFT problems
Which drug is used in combination with Memantine(Namenda)
Donepezil (Aricept)
What is the MOA of Donepezil (Aricept)
Centrally acting cholinesterase inhibitor
What are the drug interactions of Donepezil (Aricept)

All are both inducer/inhibitors
What are the indications of Aricept?
mild to moderate dementia
How is Rivastigmine (Excelon)eliminated?
By the kidneys
T/F If you are on Aricept you should NOT use Excelon, shouldn’t be on both
Which drug stimulates the nicotinic receptors to increase ach at synapse. It may also increase serotonin and glutamate
Galantamine (Razadyne)
What are the drug interactions of Galantamine (Razadyne)?
SSRI(it affects serotonin), antifungals
What do you monitor in a pt who's on Galantamine (Razadyne?)
Look at LFT and renal function

This drug is eliminated by kidney and liver
Which drug is an NMDA receptor antagonist
Memantine (Namenda)
T/F Namenda can be combined with cholinesterase inhibitors (e.g. Aricept)
Which substance overstimulates the N-methyl-D-Asprtate NMDA receptors that can result in neuronal damage
T/F Inhibition of Nicotinic receptors impairs cognition and stimulation of nicotinic receptors may improve memory