Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/24

Click to flip

24 Cards in this Set

  • Front
  • Back
Name the types of dementia
Alzheimer’s
Vascular– CAD long term
Dementia with Lewy bodies (Parkinson like)
Frontotemporal-(most deleriums attributed to this area)
What are the hallmarks of dementia?
Amyloid-beta(Aβ or Abeta)
Neurofibrillary tangles
Neuronal degeneration
What are the signs/symptoms of dementia?
Decline in activities of daily living
Changes in personality
Increase in resource utilization
e.g. Ask people to do you favors more than usual
Name some meds that can cause ALOC
Antibiotics(e.g. Fluoroquinolones – causes CNS effects – altered mental status)
Antihypertensives(e.g. Propanolol – crosses the blood brain barrier (BBB))
Anti-manics(Thorazine, Olanzapine – atypical and typical anti-psychotics)
Anti-parkinsonian
Anti-histamines(cause sedation, anti-cholinergic like effects)
H2 antagonist
Narcotics
Muscle relaxants(Flexeril, Cyclobenzapine)
NSAIDS(can cause renal toxicity)
What would you look for in a CBC on a pt with ALOC
Check if infection(Meningitis etc…)
Electrolytes(hyper/hyponatremia etc…)
Glucose (hypoglycemic)
BUN/SCr ratio (can tell us if we are dehydrated)
If ratio is greater than 20, we can be dehydrated
Why are LFTs important to check in a pt with ALOC?
Hepatic encephalopathy
T/F Folic acid toxicity can cause dementia
FALSE: Folic acid deficiency causes dementia
What agents are used to Tx dementia?
Galantamine
Memantine(Namenda)
Exelon
Aricept
Tacrine
What is the MOA of Tacrine (Cognex)?
Cholinesterase inhibitor; Elevates ACH in cerebral cortex by slowing the degradation of ACH
What is the drug interactions of Tacrine?
Theophyllline
Which drug is hardly ever used anymore due to LFT problems
Tacrine
Which drug is used in combination with Memantine(Namenda)
Donepezil (Aricept)
What is the MOA of Donepezil (Aricept)
Centrally acting cholinesterase inhibitor
What are the drug interactions of Donepezil (Aricept)
Dilantin
Phenobarb
Rifampin

All are both inducer/inhibitors
What are the indications of Aricept?
mild to moderate dementia
How is Rivastigmine (Excelon)eliminated?
By the kidneys
T/F If you are on Aricept you should NOT use Excelon, shouldn’t be on both
TRUE
Which drug stimulates the nicotinic receptors to increase ach at synapse. It may also increase serotonin and glutamate
Galantamine (Razadyne)
What are the drug interactions of Galantamine (Razadyne)?
SSRI(it affects serotonin), antifungals
What do you monitor in a pt who's on Galantamine (Razadyne?)
Look at LFT and renal function

This drug is eliminated by kidney and liver
Which drug is an NMDA receptor antagonist
Memantine (Namenda)
T/F Namenda can be combined with cholinesterase inhibitors (e.g. Aricept)
TRUE
Which substance overstimulates the N-methyl-D-Asprtate NMDA receptors that can result in neuronal damage
Glutamate
T/F Inhibition of Nicotinic receptors impairs cognition and stimulation of nicotinic receptors may improve memory
TRUE