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31 Cards in this Set
- Front
- Back
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In the elderly, decreased protein binding may be d/t:
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Disease states
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Drug distribution in the elderly is affected by: lean body mass decrease by
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10%
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Drug distribution in the elderly is affected by: body fat increases from:
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18-36% in men and 33-48% in women
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Increased body fat means there is increased available storage sites for:
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Lipid soluble drugs
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Increased body fat means that there will be and increase in:
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Residual plasma concentration
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Increased body fat means that there can be increase in _____ and _______
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Elimination times; prolonged effects
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In the elderly, decreased CO and delayed clearance mean that: there is a delay of onset of:
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IV drugs
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In the elderly, decreased CO and delayed clearance mean that: drugs have a
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Prolonged effect
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In the elderly, decreased CO and delayed clearance mean that: there is a risk of ________ OD
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Volatile anesthetic
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In the elderly, increase in elimination half time is d/t: decreased
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Renal clearance
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GFR decreases _______ per year up to 30-40%
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1.5%
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Number of effective _______ decreases --> decreased renal clearance
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Renal glomeruli
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Increase in elimination half time is d/t:
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Decreased hepatic clearance
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Increase in elimination half time is d/t:
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Increase in Vd
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There is a decrease in _______ blood flow
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Hepatic
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There is reduced hepatic _______ activity
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Microsomal enzyme
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Induction agents have a slower
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Onset
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You should decrease the dose of
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Induction agents
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Narcotics have an increased:
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Half life
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You should decrease the dose by 50% of this narcotic
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Remi
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Remi ______ last much longer than usual in the elderly
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Won't
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Muscle relaxants have a ______ but same initial dose
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Slower onset
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All muscle relaxants except _______ have reduced clearance and increased elimination half time
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Atracurium/cisatracurium
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Decreased MAC of ______ for each decade over 40
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6%
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In the elderly, _______ inhalation agents are less metabolized
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Iso and Des
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All inhalational agents depress ______ and produce _____
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Contractility; peripheral vasodilation
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Elderly have a decreased CO which means you have a more rapid rise of ________ concentration of agents
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Alveolar, arterial and tissue
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More rapid rise of concentration of agents means that you have an accelerated rate of:
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Induction
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Elderly pts have a ______ physiologic reserve
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Decreased
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Doses of narcotic required for relief of pain do _____ show a consistent change with age
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Not
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Narcotic s/e may be more ______ than in a younger person
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Drastic
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