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30 Cards in this Set
- Front
- Back
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Peds: receptors have a _______ for non-depolarizing muscle relaxants
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Lower affinity
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Maturation of receptors for NDNMB is not complete until about:
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2 months of age (preterm less)
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B/c of larger Vd, initial doses of NDNMB are _______ as adults
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The same
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Exception to dosing of NMB:
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Succs
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Infants and small children (<2) appear ______ to succs
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Resistant
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Reason that infants and small children (<2) appear resistant to succs is not clear other than:
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Increased Vd
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Dose of IM succs:
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4mg/kg
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Neonates and infants succs dose:
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2-3 mg/kg
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Children succs dose:
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1-2 mg/kg
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Neonates and infants require a _______ of succs
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Higher
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There is a greater _______ seen with the same or smaller doses of muscle relaxants
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Reduction in ventilation
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Infant diaphragm is shaped:
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Differently
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Diaphragm is paralyzed simultaneously with:
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Peripheral muscles
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Last thing to be paralyzed in the adult:
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Diaphragm
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Peds: not affected by age related effects on renal and hepatic function
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Hoffmann elimination and ester hydrolysis
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There is a greater risk with elderly pts d/t:
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Basic decline in organ fx and higher prevalence of concomitant dz
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Elderly have a ______ vascular volume
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Contracted
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A contracted vascular volume-->
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High initial plasma concentration
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Elderly have ________ protein binding
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Decreased
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Decreased protein binding -->
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Increased availability of free drug
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Elderly have increased total body ______ storage sites
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Lipid
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Increased lipid storage sites -->
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Prolonged action of lipid-soluble drugs
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Elderly have decreased ________ blood flow
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Renal and hepatic
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Decreased renal and hepatic blood flow-->
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Prolonged actions of drugs dependent on kidney and liver elimination
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Elderly generally require _____ dosages
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Reduced
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Elderly have a prolonged ______ of medications
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DOA
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Elderly have ______ reduction in blood volume
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20-30%
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Reduction in blood volume results in higher than expected:
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Plasma concentration
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Elderly have decreased protein binding d/t:
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Decreased level of serum protein
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Elderly have decreased protein binding which may be a problem with ______ drugs
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Co-administered
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