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17 Cards in this Set
- Front
- Back
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AmphoB (Fungizone / Amphotec)
zone = topical/oral (nonsys) tec = systemic |
Punches ergosterol
Binds to cholesterol-->toxicity. KIDNEY TOXICITY |
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Nystatin
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Punches ergosterol.
Binds to cholesterol-->toxicity CAN'T be used systemic, wayy too toxic. Very similar to AmphoB. BAD TASTE |
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Flucytosine (Ancabon)
IV or oral |
A PRODRUG. Disrupts fungal RNA and protein synthesis. Also for cancer tx (5-FU) --> BONE MARROW toxicity (->anemia/leukopenia/thrombocytopenia)
Good for severe systemics |
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Griseofulvin (Fulvicin)
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Oral. Mitotic spindle poison for fungal infections under nails and scalp.
Best absorbed with fatty meal, enzyme inducer. |
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Azole drugs
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Higher TI than ampho or flucytosine. Inhibit cyto-450 on fungii, blocks precursor to ergosterol formation.
All of them have 3A4 INHIBITION effects!! |
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Ketoconazole
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Azole drug with highest 3A4 interactions.
Will cause increases in: cyclosporine, terfenadine, astemizole, and warfarin Occasional severe liver toxicity. |
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Fluconazole
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Most common systemic azole prescribed!!! For candidiasis.
Unique: good penetration into the CNS!! Also fewest p450 problems of the azoles. |
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Clotrimazole
Miconazole |
Topical creams/rectal to treat vaginal candidiasis
Clotrimazole: also for oral candidiasis, better tasting that nystatin. |
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Enfuvirtide
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Fusion inhibitor for HIV tx, binds to HIV prevents fusion to host.
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Maraviroc
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Binds to T-cell, prevents HIV entry.
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Amantadine
Rimantadine |
blocks viral uncoating
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Acyclovir
Valacyclovir |
Val --> Acyclo (it's a prodrug)
For HERPES INFECTIONS |
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Ganciclovir
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needs to be phosphorylated for activation...
Treats CYTOMEGALOVIRUS 100x more potent that acyclo or valacyclo Supresses bone marrow |
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Zidovudine - bone marrow
Didanosine - pancreas Lamivudine |
Reverse transcriptase inhibitors
Often cocktailed together. |
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-Navir's
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Late protein synth / protease inhibitors
Cocktail with 2 reverse inhibitors + 1 navir. |
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-Mivir's
(Zanamivir / Oseltamivir) |
Neurominidase inhibitors
FOR THE FLU!!! |
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Raltegravir
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Integration inhibitor, blocks DNA from integrating with host DNA.
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