Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
14 Cards in this Set
- Front
- Back
|
Aspirin
|
pain, fever and inflammation
Irreversible COX-inhibitor in Platelets, kidney and gut decrease PG synthesis, and TXA2 |
|
|
Acetaminophen
|
Inhibits COX-3 in CNS
pain and fever, NOT inflammation |
|
|
Pain and Inflammation reducers
|
Ibuprofen
Ketoprofen Naproxen Indomethacin Piroxicam-very long half life, 200X potency |
|
|
Selective COX2 inhibitors
|
Celecoxib
Rofecoxib Valdecoxib -increased risk of CV event due to dec. PG, less inhibition of PLT |
|
|
Antirheumatic Drugs
|
Gold Salts
Methotrexate Chloramucil Cyclophsphamide Cyclosporine Penicillamine Sulfasalazine |
|
|
Methotrexate
|
inhibits DNA synthesis
immunosuppressant retained in cells for weeks |
|
|
Chloramucil
Cyclophsphamide |
crosslinks DNA
inhibits cell replication |
|
|
Cyclosporine
|
inhibits IL-1 and IL-2 , disrupts T-cell response
|
|
|
TNF-alpha blocking agents
|
inhibits macrophage and T-cell function
Adalimumab Infliximab Etanercept Lefunomide |
|
|
Drugs that prevent Gout
|
Allopurinol
Probenecid and Sulfinpyrazone and high-dose salicylates |
|
|
Allopurinol
|
xanthine oxidase inhibitor, purine analog
lasts a long time give if too much uric acid being produced (> 800 mg) |
|
|
Probenecid and Sulfinpyrazone and high-dose salicylates
|
inhibit proximal tubular reabsorption, lost in urine
use if uric acid excreted is < 800 mg (too little is being excreted, this will increase the clearance!) |
|
|
Drugs to treat Gout attacks
|
Colchicine
NSAIDs- only nonsalicylates -Ibuprofen, Naproxen, Ketoprofen -NO ASPIRIN |
|
|
Colchicine
|
Prevents polymerization of tubulin into microtubules
inhibits leukocyte migration inhibits synthesis and release of leukotrienes |
