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30 Cards in this Set
- Front
- Back
- 3rd side (hint)
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(1) Target Cell: Growth Hormone Releasing Hormone (GHRH) = stomatocrinin (2) Product induced
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Somato-trophs (anterior)
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GH = somato-tropin
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(1) Target Cell: GH inhibitory hormone = somatostatin = somatotropin release inhibiting factor = SRIF (2) Product induced
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Somato-trophs (anterior)
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GH = somato-tropin
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Target Cell: Corticotropin releasing hormone (CRH) (2) Product induced
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Cortico-trophs (anterior)
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ACTH
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Target Cell: Thyrotropin releasing hormone (TRH) (2) Product induced
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Thyro-trophs (anterior)
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TSH
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Target Cell: Gonadotropin releasing hormone (GnRH) (2) Product induced
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Gonado-trophs (anterior)
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FSH & LH
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Target Cell: Prolactin inhibitory hormone (PIH) = DOPAMINE (no releasing hormone) (2) Product INHIBITED
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Lacto-trophs
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Prolactin
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Target Location: Oxytocin
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stored in posterior pituitary
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Target Location: Vasopressin = ADH
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stored in posterior pituitary
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(1) Target: GH = somato-tropin (2) Target Product
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Liver
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Somatomedin-3 = IGF-1, (IGF is measurable assay for GH)
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(1)Target: ACTH (2) Target Product
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Adrenal cortex
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Mineralo-corticoids (aldosterone) & Glucocorticoids (cortisol)
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(1)Target: TSH (2) Target Product
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Thyroid
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T4/T3, T4 = circulating, T3 = biologically active
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(1)Target: FSH
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Ovaries (F) & Testes (M)
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(1)Target: LH (2) Target Product
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Ovaries (F) & Leydig (M)
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Estrogen (F), Testosterone (M)
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(1)Target: Prolactin
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Mammary glands
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(1) Target: Oxytocin
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Uterus, vagina, myoepi cells
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(1) Target: Vassopressin = ADH
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Renal tubules, smooth mm
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GH (1) Result (2) Disease
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Growth (muscle, bone, fat cells)
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GH deficit = Dwarfism, Excess GH = acromegaly (pituitary tumor)
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ACTH (1) Result (2) Disease
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GC: protein catabolism, inhibit protein synthesis, MC: Na+/H2O resorption, K+ excretion distal tubule; Na+/H2O resorb colon
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Excess (ACTH or GC) =hyeradrenocortiicism or Cushing’s & Deficit (ACTH [rare] or GC) = secondary hypoadrenocorticism or Addison’s
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TSH (1) Result (2) Disease
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Increase metabolism, Calorigenesis, Protein catabolism, increase sens to catecholamines, Brain, skeletal growth
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Hypothyroid = low T4, elevated TSH & Hyperthyroid = high T4
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FSH (1) Result (2) Disease
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Follicle development, Spermatogenesis
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LH (1) Result (2) Disease
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None
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Dz rare in small animals
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Prolactin (1) Result (2) Disease
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Postpartum lactation
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Hyperprolactinemia (pituitary tumor; galactorrhea, excess milk)
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Oxytocin (1) Cause (2) Disease
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Caused by senstory stimulli from from vagina, uterus, suckling
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treat dytocia, used to induce labor and milk letdown
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Vasopressin (1) Result (2) Disease
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Resorption of water in collecting ducts, causes release of Von Willebrand factor
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Diabetes insipidus (lack ADH = central, lack receptors = nephrogenic), SI-ADH = too much ADH release > hoponatremia, dementia
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Treatment (1) Dwarfism (2) Acromegaly
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GH analogs
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somatostatin analog (octreotide), GH-R antagonists, DA-R agonists
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Testing (1) Cushing's (2) Addison's
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ACTH (Cosyntropin) stim: Cushinoid > high cortisol
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ACTH (Cosyntropin) stim: Addisonian > low cortisol
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Treatment (1) Hypothyroid (2) Hyperthyroid
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Methimazole
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L-Thyroxine
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Treatment (1) FSH (2) LH
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PMSG (pregnant mare serum gonadotropin) has FSH activity
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HCG (human chorionic Gonadotropin) has LH activity (used in humans)
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Treatment (1) oxytocin (2) vasopressin
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dystocia, labor, milk letdown
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CPR, Von Willebrand's Disease
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what kind of endocrine drugs are possible? (2) how does the Hypothalamus-pituitary axis function?
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(1) hormone substitutes/analogs, (2) hormone synthesis inhibitors (3) hormone receptor antagonists
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hypothalamus stimulates anterior pituitary produces and stores TSH, ACTH, LH, FSH, GH, prolactin & hypothalamus produces oxytocin and vasopressin which are stored in the posterior pituitary
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