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13 Cards in this Set
- Front
- Back
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How do Statins work?
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competitively inhibit HMG-CoA reductase
increase # of LDL receptors Dec. total chol, LDL, and TG short 1/2 |
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Statins
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Atorvastin
Fluvastatin Lovastatin Pravastatin Rosuvastatin Simvastatin |
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Atorvastin
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long t1/2 (11-14hr), can be administered anytime
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Fluvastatin
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LEAST likely to cause myopathy
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Bile Acid-binding Resins
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Tx for ppl not tolerating other drugs; additive effects with other drugs
no absorption in gut Cholestyramine Colestipol Colesevalam |
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Ezetimibe
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inhibits absorption of cholesterol
Decreases LDL (20%), decreases TG. Increases HDL alone or with statin |
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Fibric Acid
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Fenofibrate
Gemfibrozil increase VLDL clearance decrease TG levels |
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Nicotinic acid (niacin)
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fix-all
Decreases LDL and TG Increases HDL |
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Best for decreasing LDL
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statins-best
Niacin- good, complications Ezetimibe- good |
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Best for increasing HDL
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Niacin
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Best for decreasing TG
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Niacin-best, complications
Statins-good |
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complications of Niacin
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Gastric irritation, increased risk of myopathy
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Niacin-statin combos
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best- niacin and fluvastatin
worst- niacin and lovastatin |
