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13 Cards in this Set

  • Front
  • Back
How do Statins work?
competitively inhibit HMG-CoA reductase
increase # of LDL receptors
Dec. total chol, LDL, and TG
short 1/2
Statins
Atorvastin
Fluvastatin
Lovastatin
Pravastatin
Rosuvastatin
Simvastatin
Atorvastin
long t1/2 (11-14hr), can be administered anytime
Fluvastatin
LEAST likely to cause myopathy
Bile Acid-binding Resins
Tx for ppl not tolerating other drugs; additive effects with other drugs
no absorption in gut
Cholestyramine
Colestipol
Colesevalam
Ezetimibe
inhibits absorption of cholesterol
Decreases LDL (20%), decreases TG. Increases HDL
alone or with statin
Fibric Acid
Fenofibrate
Gemfibrozil
increase VLDL clearance
decrease TG levels
Nicotinic acid (niacin)
fix-all
Decreases LDL and TG
Increases HDL
Best for decreasing LDL
statins-best
Niacin- good, complications
Ezetimibe- good
Best for increasing HDL
Niacin
Best for decreasing TG
Niacin-best, complications
Statins-good
complications of Niacin
Gastric irritation, increased risk of myopathy
Niacin-statin combos
best- niacin and fluvastatin
worst- niacin and lovastatin