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39 Cards in this Set

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  • Back
name 3 dopamine receptors
phenothiazines
butyrophenone
benzamides
How do you treat N/V
With anticholinergic agents:

Scopolamine-M1 recept.blocker

Antihistamines:
Benadryl
Dramamine
phenergan
name some causes of N/V
Post-Op
Obstruction
Chemo
Gastroenteritis
Pregnancy
Meniere's
what is the vomiting center of the brain called?
CTZ Zone and Area postrema in the lower medulla
what is the MOA of phenothiazines?
D2 Blockers in postrema
name 2 phenothiazines
Companzine
Thorazine
drug used for acute dystonias
Benadryl
Name a Benzamide that stimulates cholinergic receptors on gastrin smooth muscle
Reglan
Name a butyrophenone tha has a short half-life and one with a long half-life
Short - Inapsine
Long - Haldol (18 Hrs)
Name 2 serotonin antagonists
Aloxi-very expensive
Zofran
which N/V drugs are safe with pregnant women?
Zofran, it's a serotonin Antogonist
Define Cytochrome P-450
heme containing enzymes responsible for phase I metabolism
They're located in the smooth ER of Liver, small intestine and brain
what hormone can be used to treat hyperkalemia
insulin because it brings K back into the cells
Tx for hypercalcemia
Loops (lasix 80 mg IV Q1-4 hr)
Calcitonin 4 IU/kg Q12
Biphosphonates: pamidronate
give 3 causes of hypophosphatemia
phosphate binders
diuretics
refeeding syndrome
Tx for hypophosphatemia
0.5 mmols of phosphorus/kg over 4 hours
what do Inducers do?
speed up the metabolism of drugs
name some Inducers of the CYP 3A4
B-barbituates
C-carbamazipine
G-Grisflavin
R-rifampin
P-phenytoin
Name some Inhibitors
K-ketocanazole
C-carbamazipine
I-isoniazid
E-ethanol
F-phenitoin(dilantin)
what is unique about ethanol and the 2E1 cytochrome
Ethanol:

acutely=Inducer
chronincally=inhibitor
Name some protease inhibitors
Ritonavir
Indinavir
Saquinavir
Nelfinavir
Which of the following can cause hypercalcemia?
Thiazides
How would you treat mild to moderate GERD?
H2 antagonists:

Cimetidine (Tagament) Famotidine (Pepcid) Nizatidine (Axid)
Ranitidine (Zantac)
Name some PPIs
Lansorazole (previcid) Esmeprazole (Nexium) Omerazole (Prilosec) Pantoprazole (Protonix) Rapeprozole (Acid Hex)
Which drug inhibits warfarin and phenytoin?
Cimetidine (tagament)
Name some drugs that can give you hyponatremia
SSRIs, NSAIDs, Cisplatin, Carbamazipine, Vasopressin, Morphine
T/F Furosimide a Loop Diuretic can cause Hypercalcemia?
False, they cause hypocalcemia
Digoxin Toxicity can be caused by which electrolyte abnormality
Hypokalemia
Best regimen for H pylori
One PPI and two antibiotics such as:

Lanzopozole (PPI) Amoxicillin
Clarithromycin

if patient is penicillin allergic then give Metronidazole in place of Amoxicillin
what are the two most important electrolytes to monitor?
Calcium and potassium
How long do you treat gastric ulcers and duodenal ulcers?
Gastric - 4-6 weeks

Duodenal - 8-12 weeks
Name the causes of Hyperkalemia
Renal faiulure, Rhabdomyolysis, TLS, Burns/Tissue trauma, Metabolic or lactic acidosis. Drug induced: K sparring diuretics, ACE inhibitors, ARBs, Bactrim, cyclosporine, digoxin toxicity, Heparin, pentamidine
Name some side effects of cannabinoids
Xerostomia
Vertigo
Hypotension
what is phase 2 of drug metabolism?
Synthesis and oxydation
name some 1A2 inhibitors
Cimetidine
Quinololes
name one 1A2 inducer
Tobacco
name a 2C9 inducer
Rifampin
name a 2E1 inducer
ethanol(acutely), and isoniazid
name some 2D6 inhibitors
Cimetidin
Ritonavir
Paroxetine(Paxil; SSRI)