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30 Cards in this Set
- Front
- Back
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Magnesium competes with Ca for binding sites on ______ preventing increase in free _____ thus preventing the formation of the actomyocin complex which is necessary for muscular cx
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SR; Ca
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Mag is administered IV bolus followed by:
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Continuous infusion
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Mag therapeutic blood levels:
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5-8 mg/dL
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Check serum mag levels every:
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6 hours
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Mag toxicity: at 10-12 mg/dL you see
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Absent patellar reflex
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Mag toxicity: above 12 mg/dL you can have
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Respiratory arrest
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Mag toxicity: higher levels such as 20 mg/dL can produce
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Direct cardiac arrest
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Mag toxicity: treatment
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Calcium gluconate 1 Gm IV
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Mag toxicity: you also see decrease in:
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Fetal movement and HR, beat to beat variability
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Mag is used as a tx for PIH to:
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Prevent convulsions
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Mag has a mild effect on:
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Blood pressure
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Mag has an anticonvulsant effect at blood levels:
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> 7 mg/dL
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Dizziness, blurred vision, c/p, N, h/a, flushing, drowsiness, dry mouth
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S/e of mag
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Mag attenuates the release of:
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Ach at NMJ
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Mag has a mild intrinsic _____ effect
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NMB
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Mag potentiates:
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NMB
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With mag and use of NMB, you need to be careful when evaluating the:
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Reversal
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Mag is dependent upon ______ for excretion
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Renal fx
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Mag crosses
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Placenta
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Mag may cause ______ in mother; as it reduces the ability of the heart to pump
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Pulmonary edema
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Up until recently, were the most widely used tocolytics
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Beta-mimetics
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MOA of beta mimetics
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Stimulate B receptors in uterus
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Stimulation of B receptors in uterus cause activation of:
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Adenyl cyclase
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Adenyl cyclase causes:
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Synthesis of cAMP
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cAMP causes uptake of ______ into vesicles
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Intracellular Ca
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cAMP activates protein kinase which:
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Deactivates actomyocin complex
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Stimulation of B receptors in the uterus causes what effect:
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Relaxation
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S/e of beta mime tics are to the generalized:
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Beta 1 and 2 stimulation
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Beta-mimetics have ____ complications
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Metabolic, CNS, cardiopulmonary
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CNS s/e of B mimetics
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Restlessness, tremors, agitation
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