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18 Cards in this Set
- Front
- Back
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T or F g-corts are good drugs for anaphylaxis
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FALSE g-corts need time to act
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g-corts and cancer
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kills cancer cells in lymphomas and leukeimias
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g-corts and babies
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premature infants lack surfactant and g-corts facilitate formation of surfactant
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surfactant molecule
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phosphatidyl choline --> lysophosphatidylcholine
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how do you take a person off g-corts
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taper the dose g-corts have a neg feedback wrt the ant. pit. gland in that they reduce ACTH
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g-corts negative feedback
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wrt ACTH so you need to taper the dose of g-corts
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mineral imbalances
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high doses of g-corts
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g-corts stimulate gluconeogenesis or glycolysis
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neogen
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list some risks associated w/ g-corts
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infection (from immunosuppresion) cataracts osteoporosis mood swings/ insomnia fat redistribution = moon face
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moon face fat distribution
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g-corts
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short intermed long acting g-corts
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short = hydrocortisone intermed = prednisone long = flutacasone
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action times of hydrocortisone prednisone flutacasone
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8-12 12-36 24-48 hrs
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hydrocortisone has a half life of ___ but action time of ___
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half life of 90 min but action time of 8-12 hrs
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which drug is an aldosterone agonist? antagonist?
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agonist = fludrocortisone antagonist = spironolactone
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aldosterone, fludrocortisone and spiranolactone are what kind of molecules?
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mineralocorticoids
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spiranolactone
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antagonist of aldosterone....Tx of person who is making too much aldosterone; promotes xcretion of sodium
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fludrocortisone
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aldosterone agonist that is used to treat orthostatic hypotension
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aldosterone actions
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makes Na/K channels on lumen and new ATPase on blood side so that there is Na movement to blood (i.e. reabosorption in the KIDNEY here..........@@!!!!!!!!!!)
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