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10 Cards in this Set
- Front
- Back
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Acyclovir
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HSV
EBV VZ guanosine analog, gets p-ed by thymidine kinase incorporates into the DNA strand and terminates replication/ reading. Also competes for deoxy GTP Acyclo-GTP inhibits DNA polymerase. Resistance: changes in the thymidine kinase or its reduction in amount oral, IV, topical oral bioav 15 percent 85 excreted by kidney unchanged min ddi : methotrexate min SE t/2 2 hours Good CNS penetration concentrated in breast milk |
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Foscarnet
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CMV
Resistant Herpes Is not phosophorylated Bind and inhibits reverse transcriptase Binds to the pyrophosphate site on DNA polymerase Ony IV: controlled infusion rate Excreted: mostly renal unchanged attention in renal pts Nephrotoxic, most often in 2nd week Hypocalcemia, chelates CA, especially in pts on pentamidine (anti-protozoal PCP prophylaxis) CNS, anemia, N and D, fever, hepatotox |
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Gancyclovir/ Valgancyclovir
SE |
thrombocytopenia
granulocytopenia teratogenic in animals caution and dose adjustment in renal patients, as it is excreted unchanged in urine |
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A protease inhibitor that causese minor GI se, N and D, and its concentration is elevated by food six fold
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saquinavir
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acyclovir SE
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Neurotox (tremor, delerium)
Nephrotox (may crystallize and precipitate) DDI with methotrexate (tubular excretion) |
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What Herpes agent should not be used orally?
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Penciclovir (topical or IV)
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Pro-drug for Penciclovir?
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Famciclovir
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One key indication for Famciclovir?
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Post-herpetic neuralgia
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SE of valcyclovir
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TTP
and HUS |
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How should Foscarnet be given?
And all about Foscarnet : |
IV, controlled infusion rate
excreted in urine caution in renal patients CMV, resistant Herpes No phosphorylation is needed Inhibits RT Binds to pyrophosphate site on DNA polymerase Nephrotox Hepatotox Hypocalcemia (particularly on pentamidine) - Chelates Ca CNS effects N and D Anemia, fever |
