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26 Cards in this Set
- Front
- Back
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Propofol MOA is proposed to ________ inhibitory activity at ________ complexes. Exact mechanism is unknown.
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Increase; GABA
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Propofol is used as an IV:
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Sedative hypnotic
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PONV incidence is only _____ compared to other IV anesthetics (10-15%) and inhaled agents (25-50%).
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1-3%
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Does not appear to have _____ nor_____ which is why it is good in outpt/ambulatory settings.
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Cumulative effects; delayed arousal
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Does have a fast onset (______ sec) and a rapid _______.
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30-60; recovery
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Does must be _____ based on total ______ and ________ to desired clinical effect.
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Individualized; body wt; titrated
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It is virtually _____ in aqueous solution.
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Insoluble
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Allergy to _____ is a contraindication b/c lecithin is from _____.
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Egg; egg yolk
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Also ask about _____ allergy as some vials are produced with this as its base.
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Soybean
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Is ________ so must use sterile technique.
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Preservative free
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Due to the high degree of _____, onset of CNS effects are rapid.
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Lipid solubility
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Induction doses in the elderly should be lowered d/t their smaller:
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Vd
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Awakening is rapid (____ min) even after prolonged administration provided that _______ between compartments has not occurred.
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5-10; equilibrium
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Central effect is terminated by:
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Redistribution
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T ½ alpha is the redistribution from ______ to _______ compartments.
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Central; peripheral
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T ½ beta is the:
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Elimination from the body
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T ½ alpha is ~ ___ min to peak effect.
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1
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T ½ beta is between ______ min.
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5-10
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Elimination depends on ____ to be cleared and ______ of clearance mechanism.
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Volume; efficacy
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Propofol's clearance ____ hepatic blood flow, suggesting _____ mechanisms.
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Exceeds; extrahepatic
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Is metabolized in the:
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Liver
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Moderate cirrhosis ______ seem to affect metabolism.
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Doesn't
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Chronic hepatic cirrhosis and CRF _do/do not_ appear to prolong the effects.
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Do not
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Metabolites (_____%) are exerted primarily in the _____.
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88; urine
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CRF doesn't seem to affect _____.
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Clearance
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You should protect from:
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Light
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