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30 Cards in this Set
- Front
- Back
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Hydrolyzed ASA (salicylate) reversibly inhibits:
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Prostaglandin synthesis
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ASA: if you saturate all the plasma proteins, then you have an increased half life d/t a :
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Huge reservoir
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30% of ASA is excreted in ______ urine
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Alkaline
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2% of ASA is excreted in _____ urine
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Acidic
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Competitive inhibitor of COX
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Diflunisal
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More potent anti-inflammatory agent than ASA but no anti-pyretic effect (poor CNS penetration)
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Diflunisal
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Used for sprains, OA, rheumatoid arthritis. Less GI upset and anti-platelet effects than ASA
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Diflunisal
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Anti-microbial used for UC and regional enteritis. Is a type of salicylate
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Sulfasalazine
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Sulfasalazine is _______ in the GI tract and that's why it is good for treating UC
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Poorly absorbed
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Sulfasalazine may have a high risk for:
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Hepatic damage
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Metabolite of sulfasalazine
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Olsalazine
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Gastric ulceration and bleeding s/e of salicylic acid I is a ________ phenomenon
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Dose dependent
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GI bleeding may be only partially mediated by:
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COX1 inhibition
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Responsible for increasing the level of gastric mucosal secretions which is protective against acids
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COX1
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Has a cross sensitivity to other NSAIDS such as indomethacin
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ASA
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High doses of ASA can result in:
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CNS-salicylism
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Salicylates can cause early respiratory _________ d/t _____ (in adults)
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Alkalosis, hyperventilation
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Salicylates can cause late respiratory and metabolic _______ (in adults)
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Acidosis
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Salicylates in infants cause:
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Resp and metabolic acidosis
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Use of nonselective NSAIDs is associated with a significantly increased risk of:
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Gastric and duodenal ulcers
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Majority of pts hospitalized for NSAID-induced ulcer complications have:
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No warning symptoms
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NSAID use if associated with significant ______ although the statistics are disputed
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Morbidity and mortality
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Relative risk of NSAID induced UGI toxicity does ______ with long term therapy
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Not decline
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Can be used for prevention of GI toxicity with NSAID use
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Misoprostol, proton pump inhibitors, H-2 receptor antagonist
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Synthetic analog of prostaglandin E1 used to decrease GI inflammation with salicylates or NSAIDS
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Misoprostol
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Misoprostol is expensive and s/e include:
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N and severe diarrhea
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Misoprostol can cause:
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Abortion, premature birth, birth defects
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Block gastric acid production:
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Proton pump inhibitors
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Example of proton pump inhibitor
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Omeprazole, esomeprazole
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Example of H-2 receptor antagonist:
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Famotidine
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