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31 Cards in this Set
- Front
- Back
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Rheumatic fever, rheumatoid arthritis, high dose needed (5-8 grams/day)
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Anti-inflammatory uses of NSAIDS
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NSAIDS can be used for prophylaxis of diseases d/t:
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Platelet aggregation
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NSAIDS can be used for pre-eclampsia and HTN of pregnancy d/t excess:
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TXA2
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NSAIDS and CA? have the strongest evidence as protective effect against:
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Colorectal cancer
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NSAIDS only affect:
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Cyclo-oxygenase
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NSAIDS do not affect:
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Leukotrienes
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Cause alteration of vascular permeability, bronchial constriction, increased secretion
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Prostaglandins and thromboxane
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Causes leukocyte modulation --> inflammation
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Thromboxane
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______ are given as they are more effective than NSAIDS as they affect both sides of the arachidonic acid pathway
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Steroids
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Affected by cycle-oxygenase:
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Prostaglandins, thromboxane, prostacyclin
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Causes: vasodilation, erythema, hyperalgesia, pain
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Inflammatory effects of prostaglandins
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Other effects of prostaglandins:
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Increase uterine cx, GI secretions, fever, renal function, fluid retention, HTN
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Formed from arachadonic acid by 5-lipoxygenase
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Leukotrienes
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LT have many important roles in:
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Inflammation
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LT: _____ of inflammatory cells
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Chemotaxis
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LT: increase ______
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Capillary permeability
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LT: especially important in ______
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Asthma
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LT can be a cause of:
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Pain
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Cyclooxygenase is also called:
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COX enzymes
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Expressed in most tissues; constitutively active in many tissues
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COX-1
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Induced by cytokines and other inflammatory mediators
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COX-2
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Constitutively active only in some tissues (kidneys and brain)
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COX-2
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Do not have to have a pathological process going on for it to be active:
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COX-1
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Involved in lots of processes, mucous in GI tract, etc. It's out there doing something all the time
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COX-1
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This enzyme if the 'real' target:
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COX-2
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Most NSAIDS are non-specific inhibitors of both:
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COX-1 and 2
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Is in low abundance normally unless their is a pathological process going on:
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COX-2
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Fluid retaining affects are from the action of ________ in the kidneys
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COX-2
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Most NSAID s/e effects are from:
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COX-1
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PGE2 sensitizes pain nerve endings to the action of:
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Bradykinin, histamine, and substance P
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Blocks PGE2 formation
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NSAIDS
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