Pharm Exam 1

Front 1

phenoxybenzamine

Back 1

Dibenzyline A – adrenergic blk; nonselective Long acting & noncompetitive – forms stable covalent bond w/ A rec. site; mainly at A1
Incr. blood flow to skin, mucosa, viscera
Can cause orthostatic hypotension Control hypertension assoc w/ pheochromocytoma (fetal tumor of adrenal medulla);
Improve circulations;
Tmt of pulmonary hypertension

Front 2

phentolamine

Back 2

Regitine A – adrenergic blk; nonselective Competitive (reversible) antagonism at pre/post synaptic A sites Other effects are same Hersh’s JADA article on this

Front 3

prazosin

Back 3

Minipress A1 selective blk Competitive block on post synaptic A1 rec. ->
Lower BP Hypertension Sig hypotension can result on initial doses

Front 4

yohimbine

Back 4

Yocon, Aphrodyne A2 selective blk So, blk A2 = more release of catecholamines (mainly NE) -> more BP & HR Orthostatic hypotension; impotence due to vascular probs. Story of kid buying it as an aphrodisiac & dying of cerebral hemorrhage

Front 5

propranolol

Back 5

Inderal Non-sel B-blkr blk B1 – slows hr
blk B2 – bronchial constr Hypertension Not really used anymore

Front 6

metoprolol

Back 6

Lopressor B1 selective blk “cardio selective”

Front 7

Labetalol

Back 7

Trandate, Normodyne A & B blocking A1 blk: dec BP; no real B1 eff.
B2 blk: bronchoconstrict Antihypertensive Asthma