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70 Cards in this Set
- Front
- Back
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Norepinephrine
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Hypotension, shock, pressor agent.
Alpha & Beta Agonist - Neuronal Non-circulating |
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Epinephrine
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Allergic reactions, Shock, CPR
Alpha & Beta Agonist Action - Adrenal Medulla, Circulates |
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Dopamine
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Shock
Alpha-1 & Beta-1 & Dopamine Agonist - Precursor to NE |
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Pramiprexole
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Parkinsons, RLS
D-Agonist SE: Drowsiness |
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Fenoldopam
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Acute hypertension, renal failure
D-Agonist SE: Increase HR, Increase Ocular Pressure, Decrease in K+ |
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Isoproterenol
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Asthma, Cardiac Stimulant
Synthetic Beta Agonist - Decrease BP, Increase HR |
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Phenylephrine
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Nasal decongestant, hypotension
Selective Alpha-1 Agonist SE: CV reflex bradycardia |
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Methoxamine
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Hypotension, pressor agent
Alpha-1 Agonist |
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Clonidine
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Hypertension, Opioid withdrawal
Alpha-2 Agonist - Decrease CNS outflow, inhibit NE release, rebound HT SE: Dry mouth, Sedation, impotence |
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Alpha-Methyl-Dopa
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Hypertension (Esp Pregnancy)
Alpha-2 Agonist - Metabolized to Alpha-Methyl-NE |
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Dexmetetomidine
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Sedation/Analgesia (During Surgery)
Alpha-2 Agonist, no respiratory depression |
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Tizanidine
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Muscle Spasticity, Multiple Sclerosis
Alpha-2 Agonist, short-acting |
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Dobutamine
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CHF, Cardiac Stimulant (w/Min Change in HR)
Beta-1 Agonist, Increases CO, but has Tolerance and Desensitization |
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Albuterol
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Asthma, COPD - Bronchodilator
Beta-2 Selective S: Cardiovascular |
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Ritodrine
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Pre-Mature Labor
Beta-2 Selective Agonist |
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Salmeterol
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Asthma, COPD (LABAs long lasting)
Beta-2 Selective Agonist (12hr duration) SE: Increase risk/death |
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L-Dopa
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Parkinsons Disease
Precursor to Dopamine, crosses into CNS |
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Ephedrine
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Nasal decongestant, red eyes
Alpha and Beta Agonist, indirectly aids release NE |
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Amphetamine
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Narcolepsy, hyperactivity
Displaces NE, CNS stimulant SE: Tolerance, tachyphylaxis |
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Methylphenidate (Ritalin)
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ADHD
Displaces NE, CNS stimulant SE: Tolerance, tachyphylaxis |
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Tyramine
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No Indications - High is red wine & cheese
Interaction with MAO inhibitors leading to hypertension |
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Phenoxybenzamine
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Pheochromocytoma, acute & chronic HT
Alpha-1 antagonist, irreversible covalent bond S: Postural Hypotension, reflex Increase HR |
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Phentolamine
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Pheochromocytoma, acute HT
Alpha Antagonist, competitive S: Postural Hypotension, reflex tachycardia |
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Prazosin
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Hypertension, benign prostrate hypertrophy
Alpha-1 Antagonist, competitive - No reflex tachycardia S: Postural Hypotension, nausea, drowsiness |
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Propranolol
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Hypertension, angina, arrhythmias, tremor, migraine, hyperthyroidism, panic stress, MI
Beta Antagonist - Non-selective with LA action and no ISA. |
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Pindolol
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Hypertension, angina
Beta Antagonist w/ LA and ISA. |
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Timolol
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Glaucoma (Decreases Secretion), HT, MI
Beta Antagonist (NO LA or ISA) |
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Metoprolol
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Hypertension, angina, arrhythmias, MI
Beta-1 Antagonist, LA action, no ISA - SVT arrythmia common |
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Atenolol
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Hypertension, angina
Beta-1 Antagonist, no LA or ISA. Low lipid Solubility |
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Esmolol
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Arrythmias
Beta-1 Antagonist, No LA or ISA. Very short acting (10mins) |
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Labetalol
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Hypertensive Crisis, HT
Beta and Alpha Blocker w/ partial Beta Agonist action S: Postural Hypotension |
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Carvedilol
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HF, Hypertensive Crisis, Hypertension
Beta and Alpha Blocker S: Postural Hypotension |
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Cocaine
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Drug of Abuse, Local Anesthetic
Inhibits Neuronal Uptake, Cross CNS |
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Atomoxetine
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ADHD
Inhibits Neuronal Uptake, considered non-stimulant |
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Imipramine
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Depression, inhibit neuronal uptake
TCA Toxic dose can block Muscarinic, Alpha and Histamine Receptors |
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Amitriptylline
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Depression, inhibit neuronal uptake
Toxic dose can block Muscarinic, Alpha, and Histamine receptors |
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Tranylcypromine
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Depression
Non-selective irreversible MAOI, accumulation of NE, TCA's, or SSRI's preferred |
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Selegiline
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Parkinsons Disease (MAOb)
Found in platelets, liver, kidney, CNS. Has no Tyr effect |
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Tolcapone
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Parkinsons Disease
Inh COMT, Rx w/ L-Dopa S: Liver Failure |
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Haloperidol
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Schizophrenia
D-Antagonist SE: Tachycardia, CV |
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Inamrinone
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Acute and Chronic Heart Failure
Inhibit PDE III, Increase cAMP, Increase CO |
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Acetylcholine
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Minor Ocular Procedures for Brief Miosis (Pupil Constriction)
Muscarinic/Nicotinic Agonist, short acting S: Salivation, lacrimation, urination diarrhea, ernesis, miosis, cyclopleg, bronchoconstriction, decrease in HR |
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Bethanechol
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Atonic gut, urinary retention
Muscarinic agonist - resistant to AchE |
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Pilocarpine
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Acute and Chronic Glaucoma, Xerostomia
Muscarinic Agonist - resistant to AchE - Alkaloid, increase outflow. |
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Carbachol
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Glaucoma (secondary to Pilocarpine)
Muscarinic Agonist, some Nicotinic Action - Resistant to AchE |
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Methacholine
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Ocular procedures
Muscarinic Agonist - Resistant to AchE |
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Edrophonium
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Diagnostic for Myasthenia Gravis
AchE Inhibitor, competitive and short acting |
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Physostigmine
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Reverse atropine toxicity, glaucoma (increases outflow w/miosis)
Reversible AchE Inhibitor, CNS action |
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Neostigmine
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Myasthenia gravis, reverse nmj block
AchE Inhibitor reversible - no CNS, some direct agonist action |
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Pyridostigmine
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Myasthenia gravis
Reversible AchE Inhibitor - no CNS |
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DFP (Isoflurophate)
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Glaucoma
Irreversible AchE Inhibitor T: Salivation, Lacrimation, Urination, Diarrhea, Ernesis, Miosis, Cyclopleg, Bronchoconstriction, Decreased HR |
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Organophosphate
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Glaucoma
Irreversible AchE Inhibitor T: Salivation, Lacrimation, Urination, Diarrhea, Ernesis, Miosis, Cyclopleg, Bronchoconstriction, Decreased HR |
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Echothiophate
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Glaucoma
Irreversible AchE Inhibitor T: Salivation, Lacrimation, Urination, Diarrhea, Ernesis, Miosis, Cyclopleg, Bronchoconstriction, Decreased HR |
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Vx, sarin, soman (nerve gases)
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Military Use
Irreversible AchE Inhibitor - Aging takes seconds T: Salivation, Lacrimation, Urination, Diarrhea, Ernesis, Miosis, Cyclopleg, Bronchoconstriction, Decreased HR |
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Malathion
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Insecticide (less toxic than Parathion)
Irreversible AchE Inhibitor - Aging takes hours T: Salivation, Lacrimation, Urination, Diarrhea, Ernesis, Miosis, Cyclopleg, Bronchoconstriction, Decreased HR |
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Parathion
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Insecticide (more toxic than Malathion)
Irreversible AchE Inhibitor - Aging takes hours T: Salivation, Lacrimation, Urination, Diarrhea, Ernesis, Miosis, Cyclopleg, Bronchoconstriction, Decreased HR |
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Atropine
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Reverse AChE inhibition, GI disorders, ocular (iritis), vagolysis
Competitive M-Antagonist - Decrease in GI activity Decrease in Secretions Relax Lung Myadrisis Cycloplegia Mad as a Hatter Red as a Beet Blind as a Bat Dry as a Bone Hot as a Hell |
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Ipratropium
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Asthma, COPD - Bronchodilator
Competitive M-Antagonist - Decrease in GI activity Decrease in Secretions Relax Lung Myadrisis Cycloplegia Mad as a Hatter (Unresponsive) Red as a Beet (Erythematous, direct vasodilation) Blind as a Bat (Cycloplegia) Dry as a Bone (Decreased Secretions) Hot as a Hell (Thermoregulation) |
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Tiotropium
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Asthma, COPD - Bronchodilator
Competitive M-Antagonist - Decrease in GI activity Decrease in Secretions Relax Lung Myadrisis Cycloplegia Mad as a Hatter (Unresponsive) Red as a Beet (Erythematous, direct vasodilation) Blind as a Bat (Cycloplegia) Dry as a Bone (Decreased Secretions) Hot as a Hell (Thermoregulation) |
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Benztropine
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Parkinson's Disease, esp. drug induced
Competitive M-Antagonist - Decrease in GI activity Decrease in Secretions Relax Lung Myadrisis Cycloplegia Mad as a Hatter (Unresponsive) Red as a Beet (Erythematous, direct vasodilation) Blind as a Bat (Cycloplegia) Dry as a Bone (Decreased Secretions) Hot as a Hell (Thermoregulation) |
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Scopolamine
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Motion Sickness, diarrhea, decreased secretions
Competitive M-Antagonist - Decrease in GI activity Decrease in Secretions Relax Lung Myadrisis Cycloplegia Mad as a Hatter (Unresponsive) Red as a Beet (Erythematous, direct vasodilation) Blind as a Bat (Cycloplegia) Dry as a Bone (Decreased Secretions) Hot as a Hell (Thermoregulation) |
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Propantheline
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GI-disorders (ex. mild diarrhea)
Competitive M-Antagonist - Decrease in GI activity Decrease in Secretions Relax Lung Myadrisis Cycloplegia Mad as a Hatter (Unresponsive) Red as a Beet (Erythematous, direct vasodilation) Blind as a Bat (Cycloplegia) Dry as a Bone (Decreased Secretions) Hot as a Hell (Thermoregulation) |
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Hemicholinium
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No Clinical Use
Inhibits Choline Uptake (rate limiting step) |
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Botulinus Toxin
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Facial Muscle Spasms, Strabismus, wrinkles (Botox)
Decreases Ach release (prevents vesicle fusion) Duration: 3-4 mths |
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Pralidoxime (2-PAM)
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Regenerate AchE
Must be used before aging completes |
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Nicotine
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Insecticide, cigarettes
N-agonist, (blocker) T: Convulsions, vomiting, CV |
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Trimethapan
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Lower BP during surgery
Nn competitive Antagonist Not active orally S: Postural Hypotension, mydriasis |
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Mecamylamine
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Lowers BP during surgery
Nn-competitive Antagonist Active orally S: Postural Hypotension, mydriasis (pupil dilation) |
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Acetazolamide
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Glaucoma, mountain sickness
Decreases secretion due to lack of HCO3- Oral |
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Latanoprost
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Glaucoma, Fuller Eyelashes
Increases Outflow S: Darkens pupil (irreversibly) Red Eyes, (inflammation) |
