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12 Cards in this Set
- Front
- Back
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Why does taking food before drinking help you not get drunk.
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Delays delivery to jejunum where it is absorbed and allows some metabolism.
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What is ethanol's main mechanism of action.
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Increase activity of GABA. It binds receptor and increases GABA binding to its receptor Decreases activity of glutamate pathways.
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What BAC can cause death
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0.45 or higher in non-professional drinkers.
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CV functions with ethanol.
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Cutaneous vasodilation (makes you only feel warm), core temp decreases, low amounts increase HDL and decrease LDL, approx two drinks per day are beneficial.
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Renal effects.
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Pee more by high fluid and ADH inhibition.
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Liver effects of ethanol
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Acute use engorges hepatocytes with fat. You get two NADH per each ethanol which is reduction. You are at a more reduced state overall and B-oxidation of fatty acids require NAD+. Get fat in cells. Ethanol also damages mitochondria. Can inhibit ability to metabolize carbs and fats as well. More calories get made into fat.
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Disulfiram
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inhibits aldehyde dehydrogenase. Gives you a hangover. Face feels hot, flushed and scarlet in appearance. Intense throbbing in head an dneck. may have headache. You can drink through it though.
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Acamprosate
(calcium acetyl homotaurinate) |
Restores normal NMDA signal tone that was high. Reduces craving. Possibly better at maintaining abstinence than naltrexone.
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Fomepizole
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inhibitor of ADH. Can be used to treat methanol and thylene glycol poisoning.
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Alcohol drug interactions.
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Augment other CNS depressants. Get in the way of other metabolism. At low concentrations it can induce CYP2E1 metabolism but at high doses it blocks the effect on other drugs.
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What does alcohol do to acetaminophen
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It is converted by CYP2E1 to a toxic metabolite then by GSH to unharmful. Alcohol blocks GSH and induces CYP 2E1. Oh nooo, liver damage now baby. Don't take tylenol after you drink foo.
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One beer per how many hours can keep you at .08 BAC.
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1.3 hours. Be safe kids.
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