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19 Cards in this Set
- Front
- Back
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MOA of Cardiac glycosides (eg. digoxin)
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Indirectly increase intracellular calcium and cardiac contractility by inhibit Na+/K+ ATPase
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Digoxin is used in
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Atrial fibrillation and CHF
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Digoxin toxicity can be precipitated by
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Hypokalemia
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Antidote for digoxin toxicity
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Digibind
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Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects
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Amironone, milirinone
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SE of amrinone
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Thrombocytopenia
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Beta 1 agonists used in acute CHF
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Dobutamine and dopamine
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Diuretics work in CHF by
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Reducing preload
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Beta blockers work in CHF by
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Reducing progression of heart failure (never use in acute heart failure)
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Agent used in CHF that is a selective alpha and nonselective beta blocker
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Carvedilol
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Agent used in acutely decompensated CHF resembling natriuretic peptide
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Nesiritide (Natrecor)
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Other positive inotropes
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bypyridines- inamirone and milirinone
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Used to decrease afterload and preload
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ace inhibitor captopril
vasodilators BNP |
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Angiotensin R antagonists
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losartan
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agent used for acute CHF and pulmonary edema
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furosemide- loop diuretic
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major action of cardioglycosides on effective refractory period
Atrial muscle AV node purkinje system/ventricles |
Atrial muscle- decreased
AV node- increase Ventricles/purkinje- decreased |
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Changes on ECG by digoxin
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decreased QT, increased PR, ST depression
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agents used in CHF therapy that prolongs life
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diuretics, ACE inhibitors, vasodilators
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drug with well-documented reduction in digoxin clerance
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quinidine
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