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22 Cards in this Set
- Front
- Back
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pilocarpine
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M3 agonist
- lowers intraocular pressure via miosis - circular muscle moves away from anterior chamber angle -- allows outflow of AH |
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Atropine
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ACh antagonist --> muscr.
- hyoscyamine (isomer) - - causes mydriasis by blocking parasymp activity - causes cycloplegia - prevents outflow of AH - worsens glaucoma - Decr. airway secretions - Decr. GI motility - Relaxes bladder & uterus --> urine retention **may be a prob in BPH - inhibits sweating --> Atropine fever - low dose --> bradycardia - therapeutic dose --> tachycardia |
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Sildenafil
Tadalafil Vardenafil Papaverine |
PDE5 inhibitors
inhibits conversion cGMP --> GTP allows longer relaxation --> longer erection |
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methacholine
carbachol pilocarpine |
cholinergic agonist used to treat glaucoma --> cause miosis; decr. intraocular pressure
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physostigmine
demecarium echothiophate isoflurophate |
AChesterase inhibitors
treats glaucoma ***echothiophate is long acting bc stable in aqueous solution; less lipid soluble |
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methacholine
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muscr. selective agonist
- used to diagnose bronchial hyperactivity --> asthma |
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carbachol
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musc & nicotinic
- causes miosis (contraction of circular muscle) --> decr. IOP via incr. AH outflow |
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Bethanechol
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muscr. selective **no nicotinic activity
- does not get hydrolyzed by ACHE --> long DoA - treats urine retention - treats GI hypotonia |
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Acetylcholine
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not used as a drug bc quick hydrolysis
- can causes miosis |
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Oxotremorine
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muscar. selective
- causes ataxia, tremors, spasticity --> research of Parkinson's dz |
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pilocarpine
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muscar. selective
- stimulates iris sphincter / circular muscle --> miosis --> incr. outflow of Ah --> lowers IOP |
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dyflos
isoflurophate |
organophosphates
- treats glaucoma; causes miosis |
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echothiophate
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organophosphate
- treats glaucoma; long acting bc less lipid soluble |
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soman
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organophosphate
- nerve gas |
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malathion
parathion |
organophosphates
insecticides not harmful in mammals/ birds |
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carbaryl
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carbamate
- irreversible! used as an insecticide. |
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physostigme
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carbamate - reversible -- calabar bean
- treats M.G; glaucoma; atropine toxicity (not very effective) |
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neostigmine
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carbamate - rev
- treats M.G; glaucoma; megacolon; post-op ileus (paralysis of ileum); urine retention |
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Demecarium
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carbamate rev
- glaucoma |
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Ambenonium
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carbamate rev
- MG - management |
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Pyridostigmine
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carbamate - rev
- MG - better absorbed than neostigmine longer DoA |
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edrophonium
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carbamate
very short DoA - 20mins used to diagnose MG |
