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38 Cards in this Set
- Front
- Back
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class - fast tracked, hot drugs, very expensive, protease inhibitors
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inhibition of viral maturation
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nucleoside and nucleotide analogues
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work on reverse transcriptase
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alkylating agents
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mismatched base pairs, causes cleavage, directly modifies dna structure
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platinum compounds
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turned incurable diseases into curable ones (testicular, ovarian, esophageal)
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vinca alkaloids
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inhibits polymeization, important milestone in peds leukemia, comes from the periwinkle plant
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taxanes
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inhibit depolymerization, eu tree, hyperinsensitivity
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FLT3
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acute myelogenous leukemia
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JAK2
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myeloproliferative disorders; polychthemia vera, essential throbocythemia, myloid metaplasia with myelofibrosis
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BCR-ABL/C-KIT/PDGFR
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unique to leukemia cells
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oxazolidinones
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works against gram positive bacteria
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doxycycline
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safest tetracycline, safer for kidneys, lower incidence of nausea, vomiting, superinfection
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sitagliptin
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selective inhibition of DPP IV
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doxycalciferol
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use to treat secondary hyperparathyroidism, metabolized in liver = vitamin d, supresses PTH,less hypercalcemia compared to calcitriol
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what drug dosage is dependent on the intact PTH (PTHi)
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Doxycalciferol
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lanthanum
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dissociates in lanthanum ions in gi tract which binds to phosphate
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sevelamer
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binds phosphate in the intestine inhibiting the absorption
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paricalcitol
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used to treat secondary hyperpt
- inhibition supresses pth secretion and synthesis |
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what drugs increases beta cells?
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sitagliptin
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what drug may also help in breast cancer therapy?
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SERMS
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Linezolid
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oxazolindinanes
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What class treats influenza, acne, chlaydia, and mycoplasma penumoniea?
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tetracyclines
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what class is dependent on concentration for its effects?
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aminoglycosides
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What drug is bacteriacidal?
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aminoglycosides
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stretpomycin
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aminoglycosides
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translation inhibitors
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tetracycline, doxycycline, (30s) clindamycine (50s)
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inhibition of viral uncoating
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amantadine (multiuse drug)
rimantadine |
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Inhibition of viral attachment and entry
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enfuviride (T-20)
work on cd4, hiv virus |
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nucleoside and nucleotide analoges
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"clovir"
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inhibition of viral maturation
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"navir"
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inhibition of viral release
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"mivir"
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microtubule inhibitors
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vinca alkaloids and taxanes
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what is an additional more specific pathway targeted for antineoplastic agents?
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intracellular signal transduction pathways
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proteasome inhibitors
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bortezomib (multiple myeloma, lymphoma)
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angiogenesis inhibtors
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anti-vef
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plantinum compounds
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cisplatin, carboplatin, oxaliplatin
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inhibitors of purine metabolism
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6- mercaptopurine (6-MP), azathioprine, pentostatin
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inhibitos of ribnucleotide reductase
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hydroxyurea
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EGF receptor antagonists
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"nib" and "mab"
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