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7 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Carbonic Anhydrase Inhibitors
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Acetazolamide
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Acts at proximal tubules, increases urinary HCO3, NA, K.
Used for glaucoma (topical), urinary alkalination, and mountain sickniss |
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Loop Diuretics
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Flurosemide (Lasix)
Torsemide Bumetanide Ethacrynic Acid |
Ethacrynic Acid is a non sulfa.
Works in thick ascending loop of henle Inhibits urinary NA/K/2CL co-transporter, CA, MG, Blocks uric acid elimination Used for edema, CHF, hypercalcemia, HTN when thiazide inadequate |
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Thiazides
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Chlorothiazide
Hydrochlorothiazide Indapamide* Chlorthalidone* Metolazone* *thiazide like |
Acts at distal convoluted tubules
inhibits NA/CL cotransport Used for hypertension, CHF, cirrhosis, hypercalciuria, diabetes insipidus |
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K-sparing diuretics
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(SEAT)
Spironolactone Eplerenone Amiloride Triamterene |
Spironolactone and eplerenone are competitive aldosterone antagonists
Triamterene and Amiloride are aldosterone independent diuretics acts at collecting duct aldosterone enhance reabsorption of NA and secretion of K and H aldosterone independent drugs make membrane less permeable to Na causing less Na recovery and less secretion of K and H aldosterone antagonists are used in treating hypertension and CHF, hyperkalemia, gynecomastia, eplerenon only works in presence of aldosterone, is selective aldosterone independents are used for azotemia, nephrolithiasis, edema, amiloride for Li induced diabetes insipidus |
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Osmotic Diuretics
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Mannitol
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ADH Agonist
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(Pressin's)
Vaspressin Desmopressin |
ADH facilitates water reabsoprtion by activating adenylyl cyclase
ADH reduces urine volume and increase concentration used for pituitary diabetes insipidus, desmopressin preferred for chronic therapy |
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ADH Inhibitors
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Lithium ion
Conivaptan (IV) Tolvaptan (Oral) |
ADH facilitates water reabsoprtion by activating adenylyl cyclase
ADH reduces urine volume and increase concentration used for acute HF, hypervolumic hyponatermia, euvolemic hyponatremia, cirrhosis |
