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32 Cards in this Set

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Name the 8 non-immunologic adverse drug reactions.
1) overdose… 2) pharm side effects… 3) cummulative exposure… 4) delayed toxicity (toxic dose dependent effect that occur after discontinued use)… 5) drug-drug interaction… 6) Alterations in metabolism… 7) exacerbation of existing latent, or overt disease… 8) indiosyncrasy
Name the two types of immune adverse reactions to drugs
hypersensitivity and autoimmunity
name the four different types of hypersensitivities
type I: anaphylaxis.. Type II: cytotoxic… types III: serum sickness, arthus and immune complexes… Type IV: delayed hypersensitivity / cell mediated
In drug overdose, what can cause coma blisters?
barbiturates, narcotics: "phenobarbitol"
In drug overdose, what can cuase purpura and hemorrhage?
1. anticoagulants: "coumadin and heprin"…
What drug interaction can cause a drug overdose of warfarin?
Increase Warfarin Availability: Aspirin (displaces) and cimetidine (inhibits metabolism)... Decrease Warfarin Availability: barbiturates (phenobarbital), giving a risk of overdose if barbiturate is removed.
What drug overdose can cause an overdose of penicillin?
probenecid (interferes with excretion)
name 4 drugs that can cause acne
"phenytoin, phenobarbital, lithium, prednisone"
What is melasma (chloasma) and what drug can cause this?
It a discoloration of the face on women taking birth control: orthotrycyclin
What do cummulative exposure to things like silver cause?
skin discoloration
What can cause a decrease in tetracylin absorption?
Ca/milk chelate with tetracyclin
What can alter methotrexate excretion?
probenocid can alter the excretion of both methotrexate and penicillin
What can displace methotrexate from it's plasma binding?
What can cause an exaserbation of latent acne or psoriasis?
What can cause acute intermittent prophyria?
Are immunologica adverse rxns to drugs predictable or not predictable?
What drugs can cause SLE
hydralazine, and phenytoin... maybe phenobarbital
what type of hypersensitivity is associated with the following: immediate response, IgE fixed to mast cells, Uticaria, angioedema, hypotension, shock- penicilin?
Type I
What type of hypersensitivity is related to delayed, cell mediated T-cells medicated xanthems and eczematous rxns?
Type IV
What type of hypersentivity rxn is related to serum sickness, arthus, immune complexes (Ag-Ab), palpable purpura, vasculitis, IgG/IgM, penicillin and sulfonamides?
Type III
What type of hypersensitivity rxn is caused by penicillin?
Types I, III and IV
Sensitivity to light, in type IV hypersensitivity rxns, are caused by which 2 drugs… which 2 other drugs also causes photosensitivity but is not related to type IV hypersensitivity?
Type IV hypersensitivity/photosensitivity: sulfonamide, hydrochlorothazide… also related to photosensitivity tetracyclin and methotrexate
Which hypersensitivity rxn is characterized by cytotoxic-antigen fixes to cells, non-palpable purpura
Type II
which drugs cause Sweet's syndrome
lithium, orthotricyclen, hydralazine
which 7 drugs cause steven johnson's syndrome? Which 6 drugs can cause TEN?
Steven Johnson's Syndrome: methotrexate, tetracycline, penicillin, phenobarbital, phenytoin, hydrochlorothiazine, sulfanomines… TEN:methotrexate, penicillin, phenobarbital, phenytoin, hydrochlorothiazine, sufonamides
What drug can displace methotrexate from binding?
Name two diseases that have Bullous Eruptions associated with them.
TEN and Johnson-Stevens Syndrom
Name the drug related to types I, III, and IV hypersensitivity rxns
which hypersensitivities are caused by hydrochlorathiazide?
which hypersensitivities are caused by hydrochlorathiazide? II and IV
which hypersensitivities are caused by sufonamide?
III and IV
Which drugs cause type IV hypersensitivity?
Hydrochlorothiazide, penicillin, phenytoin, barbiturates, sulfonamides
Which 2 drugs would cause these types of dermotologic rxns: - opportunistic infections, skin atrophy, impaired wound healing, hirsutism, ecchymosis, and easy bruising. Hypersensitivity reactions may manifest as allergic dermatitis, urticaria, and/or angioedema.
corticosteroids, prednisone