Pharm Dermatalogical Rxns To Drugs

Front 1

Name the 8 non-immunologic adverse drug reactions.

Back 1

1) overdose… 2) pharm side effects… 3) cummulative exposure… 4) delayed toxicity (toxic dose dependent effect that occur after discontinued use)… 5) drug-drug interaction… 6) Alterations in metabolism… 7) exacerbation of existing latent, or overt disease… 8) indiosyncrasy

Front 2

Name the two types of immune adverse reactions to drugs

Back 2

hypersensitivity and autoimmunity

Front 3

name the four different types of hypersensitivities

Back 3

type I: anaphylaxis.. Type II: cytotoxic… types III: serum sickness, arthus and immune complexes… Type IV: delayed hypersensitivity / cell mediated

Front 4

In drug overdose, what can cause coma blisters?

Back 4

barbiturates, narcotics: "phenobarbitol"

Front 5

In drug overdose, what can cuase purpura and hemorrhage?

Back 5

1. anticoagulants: "coumadin and heprin"…

Front 6

What drug interaction can cause a drug overdose of warfarin?

Back 6

Increase Warfarin Availability: Aspirin (displaces) and cimetidine (inhibits metabolism)... Decrease Warfarin Availability: barbiturates (phenobarbital), giving a risk of overdose if barbiturate is removed.

Hint 6

None

Front 7

What drug overdose can cause an overdose of penicillin?

Back 7

probenecid (interferes with excretion)

Front 8

name 4 drugs that can cause acne

Back 8

"phenytoin, phenobarbital, lithium, prednisone"

Hint 8

None

Front 9

What is melasma (chloasma) and what drug can cause this?

Back 9

It a discoloration of the face on women taking birth control: orthotrycyclin

Hint 9

None

Front 10

What do cummulative exposure to things like silver cause?

Back 10

skin discoloration

Front 11

What can cause a decrease in tetracylin absorption?

Back 11

Ca/milk chelate with tetracyclin

Front 12

What can alter methotrexate excretion?

Back 12

probenocid can alter the excretion of both methotrexate and penicillin

Front 13

What can displace methotrexate from it's plasma binding?

Back 13

sulfonaide

Front 14

What can cause an exaserbation of latent acne or psoriasis?

Back 14

lithium

Front 15

What can cause acute intermittent prophyria?

Back 15

Barbiturates

Front 16

Are immunologica adverse rxns to drugs predictable or not predictable?

Back 16

unpredictable

Front 17

What drugs can cause SLE

Back 17

hydralazine, and phenytoin... maybe phenobarbital

Hint 17

None

Front 18

what type of hypersensitivity is associated with the following: immediate response, IgE fixed to mast cells, Uticaria, angioedema, hypotension, shock- penicilin?

Back 18

Type I

Front 19

What type of hypersensitivity is related to delayed, cell mediated T-cells medicated xanthems and eczematous rxns?

Back 19

Type IV

Hint 19

None

Front 20

What type of hypersentivity rxn is related to serum sickness, arthus, immune complexes (Ag-Ab), palpable purpura, vasculitis, IgG/IgM, penicillin and sulfonamides?

Back 20

Type III

Front 21

What type of hypersensitivity rxn is caused by penicillin?

Back 21

Types I, III and IV

Front 22

Sensitivity to light, in type IV hypersensitivity rxns, are caused by which 2 drugs… which 2 other drugs also causes photosensitivity but is not related to type IV hypersensitivity?

Back 22

Type IV hypersensitivity/photosensitivity: sulfonamide, hydrochlorothazide… also related to photosensitivity tetracyclin and methotrexate

Hint 22

None

Front 23

Which hypersensitivity rxn is characterized by cytotoxic-antigen fixes to cells, non-palpable purpura

Back 23

Type II

Front 24

which drugs cause Sweet's syndrome

Back 24

lithium, orthotricyclen, hydralazine

Hint 24

None

Front 25

which 7 drugs cause steven johnson's syndrome? Which 6 drugs can cause TEN?

Back 25

Steven Johnson's Syndrome: methotrexate, tetracycline, penicillin, phenobarbital, phenytoin, hydrochlorothiazine, sulfanomines… TEN:methotrexate, penicillin, phenobarbital, phenytoin, hydrochlorothiazine, sufonamides

Hint 25

None

Front 26

What drug can displace methotrexate from binding?

Back 26

Sulfonamides

Front 27

Name two diseases that have Bullous Eruptions associated with them.

Back 27

TEN and Johnson-Stevens Syndrom

Front 28

Name the drug related to types I, III, and IV hypersensitivity rxns

Back 28

penicillin

Front 29

which hypersensitivities are caused by hydrochlorathiazide?

Back 29

which hypersensitivities are caused by hydrochlorathiazide? II and IV

Front 30

which hypersensitivities are caused by sufonamide?

Back 30

III and IV

Front 31

Which drugs cause type IV hypersensitivity?

Back 31

Hydrochlorothiazide, penicillin, phenytoin, barbiturates, sulfonamides

Front 32

Which 2 drugs would cause these types of dermotologic rxns: - opportunistic infections, skin atrophy, impaired wound healing, hirsutism, ecchymosis, and easy bruising. Hypersensitivity reactions may manifest as allergic dermatitis, urticaria, and/or angioedema.

Back 32

corticosteroids, prednisone