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23 Cards in this Set
- Front
- Back
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what's the MOA of TCAs?
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inhibit reuptake of NorEpi and Serotonin
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What are the side effects of TCAs?
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Weight gain
Hepatic obstructive jaundice Agranulocytosis Toxic Psychosis Seizures Drowsiness CNS stimulation(2nd amines) Cardiac |
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What are the cardiac side effect of TCAs?
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CHF
Heart block Prolong QT interval Hypotension Tachycardia |
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Which TCA is most activating?
Most sedating? |
Protriptyline (vivactil)
Doxepin (sinequan)-due to anticholinergic effects |
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Which TCA has the most cardiac side effects?
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Amitriptyline(Elavil)-because it affects Norepi mostly, therefore, it will cause HTN and cardiac abnormalities
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TCAs you can use for bedwetting?
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Desipramine
Imipramine Because of its anticholinergic effects |
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Which TCAs do you avoid in a pt with H/O seizures?
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Maprotiline
Amoxapine Clomipramine |
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What's an alternative to TCA if you're pt is obese?
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SSRIs because they cause anorexia
TCA cause weight gain |
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What are the 3 monoamines in the brain?
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serotonin
norepi dopamine |
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Name the MAOIs Type A
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Phenelzine (Nardil)-causes sedation
Tranylcypromine (parnate)-causes stimulation |
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Which MAOI is used in parkinson's
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Selegiline- it increases dopamine
Give at low dose because high doses reduces its selectivity |
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Adverse effects of MAOIs
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Sexual dysfunction
HTN crisis Drug interactions |
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Which drugs do MAOIs interact with?
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TCAs, SSRIs, Cocaine, Sudafed
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what should you do before starting new meds and the pt is on a MAOI?
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Need a two week wash-out
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Name the SSRIs
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Prozac
Zoloft Paxil LuVox Celexa Lexapro |
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Side effects of SSRIs
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Wt loss/anorexia- abd effects
Insomnia Sexual dysfunction Sweating Anxiety |
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What drug causes priapism, drowsiness, and orthostasis
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Trazadone
Dose: 50-600 mg/d |
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What's the side effect of Venlafaxine?
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Similar to SSRIs; high incidence of HTN
Wt loss N/V |
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What is the MOA of Mirtazapine?
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presynaptic alpha 2 antagonist, serotonin 2-3 receptor antagonist
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what are the adverse effects of Mirtazapine?
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dry mouth
wt gain increase LFTs sedation VERY SADATING |
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What is the dose of Mirtazapine?
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15-45mg/day at bed time
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what drugs are used for OCD?
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SSRIs and clomipramine
Lithium is last line |
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What is the dosing for OCD drugs?
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Prozac 60-80 mg/d
Zoloft 100-200 mg/d Paxil 40-60 mg/d LuVox 100-300 mg/d Benzo- use when >anxiety |
