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14 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Cyclosporine
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Calcineurin inhibitor
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Binds cyclophilin=>inhibits calcineurin=>prevents dephos of NFAT=>blocks IL-2 tcr
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Tacrolimus
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Macrolide Antibiotic
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Binds FK binding protein=>inhibits calcineurin phosphatase=>blocks IL-2 tcr
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Sirolimus
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Calcineurin inhibitor
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Binds FK binding protein=>inhibits calcineurin phosphatase=>blocks IL-2 tcr. Cell arrest in G1-S phase.
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Mycophenolate mofetil
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Immunosuppressant
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Inhibits IMPDH=>inhibits lymphocyte proliferation
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Thalidomide
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Immunosuppressant
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Inhibits growth factors, induces TNFa mRNA degredation.
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Azathioprine
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Immunosuppressant: 6-mercaptopurine
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Antagonizes purine metabolism, terminates DNA chain
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Cyclophosphamide
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Phosphoramide mustard; immunosuppressant
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Cross-links DNA
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Rituximab
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Ab
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CD20
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Eculizamab
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Ab
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C5
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Anakinra
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Anti-inflammatory
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Inhibits IL-1+reduces cartilage degredation, bone resorption
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Adalimumab
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Ab
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TNFa
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Trastuzamab
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Ab
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HER2/neu
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Aldesleukin
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IL-2 analogue
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Binds IL-2 receptor=>stim growth and differentiation of T-cells
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Leflunomide
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DMARD; pyrimidine synthsis inhibitor, anti-inflammatory
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Inhibits mitochondrial DHODH=>selectively prevetns synth of lymphocytes by interfering with cell cycle
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