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14 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Colchicine
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Immunosuppressant
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Arrests mitosis in metaphase by preventing mitotic spindle formation
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Ibuprofen
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Analgesic, anti-inflammatory, antipyretic
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Inhibits COX and therefore PGE2
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Naproxyn
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NSAID
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Non-selective COX inhibitor=>less thromboxane A1 and PGE2
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Prednisone
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Steroid immunosuppressant
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Binds GR in nucleus=>mod gene tcr
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Abatacept
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Immunosuppressant
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Binds CD80 and CD86=>blocks bond between MHC and T-cell=>inhibits activation
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Anakinra
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Anti-inflammatory
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Inhibits IL-1 binding=>reduces cartilage degradation and bone resorption
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Azathioprine
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DMARD immunosuppressant
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Antagonistes purine metabolism=>chain termination=>blocks DNA, RNA, protein synthesis
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Chlorambucil
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Alkylator, immunosuppressant
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Attaches alkyl groups to DNA, crosslinks
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Cyclosporine
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Calcineurin inhibitor, immunosuppressant
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Binds cyclophilin, inhibits calcineurin, blocks IL-2
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Hydroxychloroquine
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Mild immunosuppressant
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Exact mech unknown--suppresses T-ymphocyte respon
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Methotrexate
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DMARD, anti-inflammatory
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Inhibits 5-AICAR, accum adenosine, binds A2 alpha receptors, decreases TNF, IFN, IL-2, IL-6
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Rituximab
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Ab
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Complexes with TNFa, prev binding to p55 and p75
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Inflixamab
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Ab
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Complexes with TNFa, prev binding to p55 and p75
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Etanercept
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Immunosuppressant
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Fusion of two TNF p75 receptors inhibits TNFa
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