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26 Cards in this Set
- Front
- Back
- 3rd side (hint)
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* AH 5183 (vesamicol)
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Blocks vesicle packaging
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Decreases ACh vessels
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* botulinum toxin
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Blocks vesicle release
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Decreases ACh in synapse
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* blackwidow spider venom (latrotoxin)
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attacks storage vesicles
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Transient burst of ACh release; then inhibits
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* hemicholinium
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Choline symport uptake block
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Decreases ACh
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* neostigmine
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Reversible AChE inhibitor
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Treat myasthenia gravis; +salivation; bradycardia; +brochial secretions; etc
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* pyridostigmine
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Reversible AChE inhibitor
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Treat myasthenia gravis
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* physostigmine (eserine)
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Reversible AChE inhibitor
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Antidote to atropine(+ACh in synapse; overcomes atropine); treat glaucoma
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* edrophonium
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Reversible AChE inhibitor
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Dx of myasthenia gravis; Short Acting
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* echothiophate
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Irreversible AChE inhibitor
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Treat glaucoma. + charge prevents absorption
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* di-isopropylfluorophosphate; sarin; soman
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Irreversible AChE inhibitor
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Biological warfare
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* parathion
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Irreversible AChE inhibitor
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Insectiside: bronchoconstriction; +airway secretions; bradycardia; etc.
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* chlorpyrifos
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Irreversible AChE inhibitor
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Insectiside: bronchoconstriction; +airway secretions; bradycardia; etc.
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* pralidoxime
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AChE Reactivator
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Give quickly after organophosphate poisoning(restore AChE) w/ atropine (to releave symptoms)
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* acetylcholine
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NAChR/MAChR agonist
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activates nicotinic and muscarinic receptors
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* nicotine
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Nicotinic Agonist
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tremors; toxic in children
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* succinylcholine
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Nicotinic Mixed agonist/antagonist Neuromuscular Junction Blocker
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initally activates; but sticks and blocks - Depolarizing. Surgical muscle relax. WARN: action prolonged Pt w/ atypical BChE
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* trimethaphan
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Nicotinic Antagonist: Ganglionic Blocker
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Decrease muscle and neuron excitability ->decrease motility and vascular tone. Used in hypertension emergencies
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* curare
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Nicotinic Anti – Nondepolaring Neuromuscular
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arrow dope; muscle relaxer/paralytic
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Ve;Atra;pancuronium
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Nicotinic Anti – Nondepolaring Neuromuscular
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muscle relaxer/paralytic
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* muscarine
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Muscarinic Agonist
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Poisoning from muschroom. Treat with Atropine. Liver failure
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* pilocarpine
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Muscarinic Agonist
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Decrease intraocular pressure. Glaucoma treatment; cause disphoresis(sweating).
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* bethanecol
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Muscarinic Agonist
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promote voiding/GI motility; +asthma
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* atropine
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Antagonist
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(Blocks post-synaptic ACh receptors ) Red; Hot; Dry; Mad; Blind; Seizing (blocks parasympathetic); dilate pupil; relax = far vision; +HR. Blocks baroreceptors
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* pirenzipine
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Muscarinic1 antagonist
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Atropine analog
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* scopolamine
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Muscarinic Antagonist
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Motion sickness; decrease secretions for surgery
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* carbachol
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NAChR/MAChR agonist
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Glaucoma treatment
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