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9 Cards in this Set
- Front
- Back
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Botulinium Toxin MOA
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binds to protein--> rec.-med. endocytosis
LIGHT CHAIN hydrolyzes proteins w/ SYNAPITC STORAGE of Ach stops Ach release in NMJ |
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Tetanus Toxin MOA
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acts in spinal cord to prevent release of GABA
removal of inhibition - SPASTIC PARALYSIS |
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Black Widow Spider Toxin MOA
alph-Ladrotoxin |
excessive release of Ach
binds to NEUREXINS in plasma membrane |
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Neostigmine MOA
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slowly reversible inhibitor of Achase
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Malathion MOA
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irreversible Achase inhibitor
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Sterochemistry of Ach and Receptors
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CIS = nicotinic
TRANS = muscarinic (mainly IV Ach) |
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How to get nicotinic effects from IV Ach:
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block muscarinic rec. with atropine
+ Ach |
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Methacholine
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methyl added to beta-C of Ach
***prevent stereo-conversion) -specificity to muscarinic receptors (trans) |
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Carbachol
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replace acetyl group with carbamoyl group on Ach
both cis and trans |
