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26 Cards in this Set
- Front
- Back
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Cholinergic Blocking
Pirenzepine |
antag of M1 only; inhib acid secretion
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Cholinergic Blocking
Tolterodine |
M3 antag; urinary incontinence
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Muscarinic Antag
ATROPINE Features |
2-4 hrs half life
from belladonna olant in Jimson weed tert amine, CNS in large doses blocks all M rec |
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Muscarinic Antag
ATROPINE Effects Eye |
block iris and ciliary m. contraction; loss of accomodation
topical more effective mydriasis (pupil dilation) |
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Muscarinic Antag
ATROPINE Effects GI |
reduces secretions and motility, stomach
delay transient through digestive dec secretions |
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Muscarinic Antag
ATROPINE Effects Temp |
dec thermoregulatory (sudomotor) sweating by blocking receptor actions of ACh
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Muscarinic Antag
ATROPINE Effects Exception |
atropine blush
dilation of blood vessels in face |
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Muscarinic Antag
ATROPINE Effects CV |
mild tachycardia
neg. on BV b.c they are not parasym controlled HOWEVER do block vasodilation and hypotension b.c block symp M rec |
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Muscarinic Antag
ATROPINE Side Effects |
dry mouth, constipation, dec sweating, inscrease susceptibility to resp infection
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Muscarinic Antag
ATROPINE Poisoning |
from smoking Jimson weed
parasym blockade, delrium, hallucinations, coma TREATMENT: physostigmine b.c penetrates CNS |
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Muscirinc Antag
SCOPOLAMINE Features |
similar to atropine
more CNS actions, drowsiness and amnesia side effects similar as well |
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Muscirinc Antag
Propantheline |
quat amine
NOT CNS peptic ulcer disease side E like atropine |
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Muscirinc Antag
IPRATROPIUM |
quat amine; inhale for rev airway disease
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Muscirinc Antag
Tiotropium |
similar to Ipratropium;
give longer bronchodilation |
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Gang Blocking Drugs
Trimethaphan |
Lower BP
Not used anymore |
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Gang Blocking Drugs
HEXAMETHONIUM |
historical interest
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Gang Blocking Drugs
Side E |
constipation
atony of UT b.c block parasym cycloplegia - paralysis of ciliary m. tachycardia b.c baroreceptor sym piring b.c of gang induced hypotensiono |
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Neuromuscular Blocking Agents
D-TUBOCURARINE Features |
not absorbed orally b.c two quat N fxns
20-40 min duration active ingredient in curare |
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Neuromuscular Blocking Agents
D-TUBOCURARINE Mech |
release histamine
reduced BP, inc resp secretions, bronchospasm |
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Neuromuscular Blocking Agents
D-TUBOCURARINE Side E |
not completely selective
some ganglionic blockade; hypotensive, paralysis of small m. |
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Neuromuscular Blocking Agents
ATRACURIUM |
similar to D-TUBOCURARINE
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Depol motor end plate blockade
SUCCINYICHOLINE Features |
Ester of 2 choline with succinic acid
short duration, IV plasma cholinesterase inactivate by taking off 1 choline action prolonged when cholinestase deficient; OR other drug (organophosphate) |
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Depol motor end plate blockade
SUCCINYICHOLINE Uses |
surgical anesthesia
orthopedic procedures to relax m. Intubation |
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Depol motor end plate blockade
SUCCINYICHOLINE Interactions anesthetics |
inc. blockade by competitive blockers; stabilize hyperpol state
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Depol motor end plate blockade
SUCCINYICHOLINE Interactions antiboitics |
can have curare like activity and increase intensity of blockade
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Depol motor end plate blockade
SUCCINYICHOLINE interactions Ca |
Ca channel blockers enchance blockade
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