Pharm - Chloramphenicol, Tetracyclines, Macrolides And Clindamycin

Front 1

Agent used to tx bacterial dysentery that causes vomiting, diarrhea with green stools, lethargy, ashen color, hypothermia, hypotension and abd distention in infants

Back 1

chloramphenicol

Front 2

MOA of tetracyclines

Back 2

block of binding of aminoacyl-tRNA to bacterial ribosome by binding to 30S subunit

Front 3

Syphilis tx in pt with penicillin allergy (2)

Back 3

tetracycline or azithromycin

Front 4

T or F about tetracycline? ingestion of antacids or multivalent cations interferes with absorption

Back 4

TRUE

Front 5

T or F about clarithromycin? eradicates mycoplasmal infections in a single dose

Back 5

FALSE

Front 6

T or F about clarithromycin? is active against strains of strep that are resistant to erythromycin

Back 6

FALSE; both are macrolides

Front 7

T or F about clarithromycin? is more active against MAC

Back 7

TRUE

Front 8

T or F about clarithromycin? isn't an inhibitor of liver drug-metab enzymes

Back 8

FALSE

Front 9

T or F about clarithromycin? is active against MRSA

Back 9

FALSE

Front 10

Mech of resistance of Gram pos to macrolides

Back 10

methylation of binding sites on 50S ribosomal subunit

Front 11

Alternalive tx for penicillin allergic pt for gonorrhea

Back 11

spectinomycin followed by oral doxycycline OR azithromycin

Front 12

Prophylactic tx of bacterial endocarditis in pt allergic to penicillins

Back 12

clindamycin 1 h before procedure

Front 13

Drug for CAP

Back 13

doxycycline

Front 14

What happens with concurrent ingestion of caffeine and erythromycin?

Back 14

erythromycin inhibits CYP1A2 which metabolizes methylxanthines, so caffeine intake can cause cardiac and CNS toxicity

Front 15

SE of telithromycin (3)

Back 15

hepatotoxicity, fainting, blurred vision

Front 16

Indication for telithromycin use

Back 16

CAP due to pneumococci resistant to other antibiotics

Front 17

Second line of tx for enterococcal bacteremia

Back 17

linezolid (first is vancomycin)

Front 18

T or F about doxycycline? bactericidal

Back 18

FALSE; bacterostatic

Front 19

T or F about doxycycline? excreted mainly in urine

Back 19

FALSE

Front 20

T or F about doxycycline? elimination half life of less than 2 h

Back 20

FALSE; > 12 h

Front 21

T or F about doxycycline? more active than tetracycline against H pylori

Back 21

FALSE

Front 22

T or F about doxycycline? used in Lyme disease

Back 22

TRUE

Front 23

T or F about streptogramins? active against E faecalis

Back 23

FALSE; only E faecium

Front 24

T or F about streptogramins? active against multidrug resistant strep

Back 24

TRUE

Front 25

T or F about streptogramins? bacteriostatic

Back 25

FALSE

Front 26

T or F about streptogramins? induce formation of hepatic drug metab enzymes

Back 26

FALSE; inhibits CYP3A4

Front 27

T or F about streptogramins? hepatotoxicity with FDA drug alerts

Back 27

FALSE

Front 28

Which drug inhibits bact protein synthesis, has a narrow spectrum, used against Bacteroides fragilis and may cause colitis?

Back 28

clindamycin

Front 29

DOC for Legionnaires' disease

Back 29

Erythromycin

Front 30

Drug causes teeth discoloration

Back 30

Tetracycline

Front 31

MOA of tetracycline

Back 31

Decreases protein synthesis by inhibiting 30S ribosome

Front 32

Drug that causes gray baby syndrome and aplastic anemia

Back 32

Chloramphenicol

Front 33

Drug notorious for causing pseudomembranous colitis

Back 33

Clindamycin

Front 34

Oral antibiotic of choice for moderate inflammatory acne

Back 34

Minocycline

Front 35

MOA of erythromycin

Back 35

Inhibition of protein synthesis at the 50s subunit of ribosome

Front 36

MOA of chloramphenicol

Back 36

inhibits transpeptidation by blocking the binding of aminoacyl moiety of tRNA after binding the 50S subunit

Front 37

MOA of streptogramins

Back 37

bind 50S subunit and constrict the exit channel on ribosome through which polypeptides are extruded

Front 38

MOA of linezolid

Back 38

binds 50S subunit and inhibits initiation of tRNA-ribosome-mRNA complex

Front 39

Tx of H pylori

Back 39

Tetracycline

Front 40

Tx of meningococcal carrier state

Back 40

Minocycline

Front 41

Tx of MRSA and VRE

Back 41

tigecycline