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9 Cards in this Set
- Front
- Back
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antifungal drugs
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fungi exist in yeast form and mold form
yeast form by budding spore formation mold form by extending hyphae(branches)/ infl. hx of travel since it is endemic |
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amphotericin-B
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mech: binds with ergosterol disrupts plasma membrane of fungal cell
route: IV life threatning/emergency status DOC: fungal infection/meningitis/UTI |
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flucystosine
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mec: inhibits thymidylate synthetase (5-FU form)
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ketoconazole
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mec:inhibits ergosterol synthetase
DOC: paracoccidioides (brazil), candidiasis, dermatophytes s/e: should not be used with amphotericinB |
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cystatin
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doc: ophtalmologic fungal infections; topical candidiasis
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clotrimazole
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DOC:topical application effective for oral thrush (candida)
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therapeutic value of fluconazole in fungal injections rest on its ability to inhibit synthesis of
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ergosterol
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iv life threatning fungal
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amphotericin B
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an azole must commonly be used for topical treatment of candidiasis
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clotimazole
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