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18 Cards in this Set
- Front
- Back
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protein synthesis inhibitor
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very broad spectrum
use: aerobic gram +/- |
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aminoglycosides
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amikacin, gentamicin, streptomycin, neomysin
route: parenteral |
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amikacin/ gentamicin
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DOC: enterobacter, ecoli, pneumonia, proteus, pseudomonas
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streptomysin
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2nd line anti-tb drug and aminoglycoside that inhibits protein synthesis
s/e: nephrotoxicity/otoxicity |
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tetracyclines:
-doxycycline -tetracycline -minocycline |
route:PO
avoid: milk, antacids, iron supp crosses BBB excretion: renal C/I: pregnant/lactating/children |
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tetracycline/doxycycline
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DOC- acne, chlamydial inf, lyme dz, spirochetes, rickettsiae, excreted in bile
s/e: GI distress, photosensitivity, impair teeth/bone growth |
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macrolides
-erythromycin -clarithromycin -azithromycin |
excretion: liver bile
C/I liver failure |
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erythromycin
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DOC-h.influenza/resp.pneumonia, mycoplasma avium, chlamydia
s/e: GI distress, ototxicity, jaundice |
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chloramphenicol
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route:PO/IV
excretion: renal cross BBB DOC:salmonella typhi, h.influ epiglottitis s/e: gray baby syndrome, anemia in G6PD Def. pt, bone marrow aplasia |
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clindamycin
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doc-bacteriodes fragilis
route: PO excretion: renal/hepatic s/e: pseumembranous colitis |
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assoc. with gray baby syndrome which is characterized by pallor, cyanosis, death?
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chloramphenicol
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safely administered at full doses to pt with renal insuff; has antimicrobial activity against gram + bacteria
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erythromycin
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mech of action: chloramphenicol
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protein synthesis inhibitor
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nephrotoxicity/ototoxicity seen in?
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streptomycin, gentamicin, amikacin
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second line treatment of TB
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streptomycin
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what inhibits protein synthesis
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a-asparaginase, deaminate, asparagine
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which antibiotic in pregnancy is not given
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tetracyclines
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member of genus streptomycin
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produce many well known antibiotics
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