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33 Cards in this Set
- Front
- Back
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Prednisone
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steroid, induces lymphocytopenia
for ALL |
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Vincristine
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binds to tubulin-->inhibits microtubulin formation-->inhibits mitosis
causes peripheral neuropathy, phlebitis, alopecia, multible GI problems for ALL |
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purimethol
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6-MP
SE: stomatitis, BM suppression, alopecia, nause vomiting, renal and hepatic damage |
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Wilms tumor
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congenital kidney tumor, occurs between age 2-5
treat: dactinomycin and vincristine |
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Hodgkins dis
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type of lympoma
treat: ABVD: adriamycin (doxorubucin), bleomycin, vincristine, dacarbaine |
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Dacarbazine
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alkylating agent
very emetogenic (premedicated with anti-emetic), BM suppression |
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Mechlorethamine
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alkylating agent of guanines in DNA
DE: nausea, vomiting, BM suppression, VZV, extensive blisters |
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procarbazine
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inhibits both DNA and RNA syntehsis
SE: BM suppression, disulfiram rxn, neurotoxicity (drowsiness that progress to hallucinations and paresthesias) |
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cylcophosmabide
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most widely used alkylating agent. active after transformed by P450. destroys DNA.
SE: alopecia, BM suppresion, leukosytosis, amenorrhea, sterility, HEMORRHAGIC CYSTITIS-->BLADDER FIRBROSIS |
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bleomycin
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casue PULMONARY FIBROSIS
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CISPLATIN
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Causes intra and inter strand cross-linking between necleotides-->cease all RNA, DNA syntheiss
for solid tumors SE: vomiting (due to activation of serotonin receptero in chemoreceptor trigger zone), nephrotox, ototox, PERIPHERAL NEUROPATHY |
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L-asparaginase
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convert asparagine into aspartic acid-->deprives cell for asparagine
treat: ALL SE: HYPERSENSITIVITIES, decrease clotting factors, liver problems, pancreatitis, seizures, coma |
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6-MP
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DOC: ALL
SE: BM suppre |
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cytatabine
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DOC: AML
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5-FN
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usullay for Colorectal cancers
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Bleomycin
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DOC: Testicular Cancer
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Vincristine
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DOC: hodgkins lymphoma
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vinblastine
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DOC: testicular cancer
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alkylating agents
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mechlorethamine, cylcophosmadie
chlorambucil, melphalan, lomustine, busulfan usually for leukemia, lymphomas can casue secondary cancers |
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cisplatin
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DOC; testicular, bladder cancer
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leuprolide
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used for prostate cancer
Se: hot flashes synthetic analog of GnRH-->suppress sex hormone syntheiss |
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flutamide
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used for prostate cancer
testosterone receptor antagonis Se: gynecomastia |
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Hydroxyurea
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inhibits ribonucleotide reductase 0enzyme key tonucleotide synthesis in WBC.
effective inhibitor of WBC proliferation also induces the synthesis of fetal hemoglobin-->useful for sickle cell pts |
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ATRA
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all-trans-retinoic acid-->binds to mutated form of retinoic acid receptor that is only found in AML cells-->causes immature neoplastic cells to complete differentiation -->become mature myeloid cells-->remision
SE: DIC |
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Tamoxifen
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inhibt estorgen receptor in Breast tissue
treat breast cancer Se: hot flases, DVT, PE, endometrial cancer |
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Taxanes (paclitaxel, docetaxel)
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inhibit microtuble disassembly-->apotosis
Se: BM depression main use: breast, lung, ovarian |
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NSAIDS
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inhibit production of PGE2: decrease pain, decrease fever
inhibit production of PGI2: increase gastric secretion inhibit PGE2, PGF2: decrease protective mucus in stomach and small intestine |
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phospholipase A2
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inhibited by corticosteroids,
increase by bradykinin, ANGII |
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asprini
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acetylase COX irreversibly both centrally and peripherally-->decrease inflammation and fever
decrease thromboxane-->decrease plateelt aggregation analgesice because wihtout prostaglandins-->peripheral pain receptors are prevented form sensitization contratindacted in GOUT because competes wiht urate for renal transporter first DOC: rheumatoid arthritis, casues uncoupling of ETC-->hypoventilation-->increase CO2 -->stimulate medulla-->cause hyperventilation-->respiratory alkalosis-->kideny tries to corrects-->causes metabolic acidosis (acidity of salicylic acid also causes metabolic acidosis)-->central resp. paralysis-->hypoventilation-->respiratory acidosis in mild cases of overdose: hyperventilation + tinnitus moderated overdose: resp. alkalosis sever overdose: respiratory acidosis |
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acetaminophen
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no peripherial anti-inflammatory
limited to CNS COX-->.reduce fever and perception of pain DOC: children with viral infx |
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PHenylbutazone
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NSAID: not currently used in US
strongly binds to albimin and can displace weakly bound drugs on albumin SE: agranulocytosis, fatal aplastic anemia |
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indomethacin
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antiinfflamtories
for sever instances such as acute gouty arthritis, ankylosing spondylitis, osteoarthritis of hip SE: GI disturbances, ulceration that may perforate and hemorrhage, pancratitis, fatal hepatits, aplastic anemia |
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nonselective NSAIDS
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ibuprofen,ketorolac, tometic, naproxen
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