Pharm. Chapt. 44 Ca+ Channel Blockers

Front 1

These are drugs that prevent Ca+ from entering the cell. They have their greatest effects on heart & blood vessels

Back 1

Ca+ Blockers

Front 2

In ******muscle, CCB act selectively on peripheral arterioles & arteries & arterioles of the heart. They have no significant effects on veins.

Back 2

Vascular Smooth Muscle

Front 3

In this part of the heart, where CCBs are introduced, Ca+channels in the atrial & ventricular muscles are blocked, whereas contractile force is diminished.

Back 3

Myocaridum

Front 4

In the part of the heart CCB's close Ca+ channels, whereby pacemaker activity declines. CBC's are used to reduce HR.

Back 4

SA Node

Front 5

In this part of the heart, CCB's are used to decrease velocity of conduction.

Back 5

AV Node

Front 6

This CCB falls under the classification of Phenyalkylamine. Blockade reduces atrial pressure, increases coronary pefusion, reduces HR at SA node, decreases AV nodal conduction & force of conduction at myocardium.

Back 6

Verapamil

Front 7

For this condition, verapamil is used for the "vasospastic" and **** effort.

Back 7

Angina Pectoris

Front 8

For this condition, verapamil is a first-line agent for chronic hypertension. Drug lowers BP by promoting dialation of arterioles.

Back 8

Essential Hypertension

Front 9

For this condition, verapamil adimin IV is used to slow ventricular rate for atrila flutter, atrial fib & paroxysmal supraventricluar tachy. Suppresses impulse conduction thru AV node.

Back 9

Cardiac Dysrhythmia

Front 10

Verpamil may be admin. IV or orally, but undergoes extensive first pass effect. Begins in 30min & peaks in 5hrs. This is an ex. of what

Back 10

Pharmacokinetics

Front 11

Two drugs which have an adverse effect on verapamil, due to the fact that both drugs will enhance slowing of the heart. If combined patients should be monitored

Back 11

Dioxin/Beta Blockers

Front 12

This drug falls under the family of dihydropyridine; but has very little blockade of Ca+ in the heart. Can't treat dysrhthmia & more likely to cause refelx tachy.

Back 12

Nifedipine

Front 13

This drug is well absorbed orally; but undergoes extensive first-pass-effect of about 50%. Begins in 20min & peaks in 6hrs.
(Repeat Question)

Back 13

Nifedipine

Front 14

For this condition, nifedipine is used in combo w/a beta blocker to prevent reflex stim. of heart, which can intensify this condtion.

Back 14

Angian Pectoris

Front 15

Nifedipine is used to treat this condition; but only is the sustained-release formulation. Used to be used in emergencies.

Back 15

Hypertenstion

Front 16

Adverse effects of this drug includes "constipation", along w/flushing, dizziness, headache, peripheral edema, & gingival hyperplasia.

Back 16

Verapamil

Front 17

Drug that has all of the adverse effects of Verapamil, w/out the constipation. It can cause reflex tachycardia.

Back 17

Nifedipine

Front 18

This form of Nifedipine has been associated w/ increased mortality in patients w/MI & unstable angina.

Back 18

Rapid-Acting Nifedipine

Front 19

Like verapamil, this drug blocks Ca+ channels in the heart & vessels. Lowers BP via arterial dialation. Used for angina, essential HT, dysrrhythmias.

Back 19

Diltizem

Front 20

This drug causes less constipation; but can exacerbate dysfunct. in pt w/bradycardia, sick sinus syndrome, HF or 2nd & 3rd degree AV Block.

Back 20

Diltizem

Front 21

This drug can also intensify beta blockers.

Back 21

Diltizem

Front 22

For this type of data, nurse must determine BP & pulse, along w/labs on liver & kidney funtc. For anginal pt, determine freq. of attacks.

Back 22

Baseline Data

Front 23

For this part of the nursing process, patient should be told to inform MD if swelling of ankles or feet occurs.

Back 23

Patient Education

Front 24

Intervention where the sustained release formulation is to be administered whole, w/out being chewed or crushed. For IV monitor for ECG for AV Block, sudden HR reduction & prolonged PR or QT interval.

Back 24

Implementation