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26 Cards in this Set
- Front
- Back
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Slightly increased risk of breast cancer, endometrial cancer, heart disease (questionable), has beneficial effects on bone loss
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Estrogen
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Antiestrogen drugs used for fertility and breast cancer respectively
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Clomiphene and tamoxifen
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Common SE of tamoxifen and raloxifene
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Hot flashes
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Selective estrogen receptor modulator (SERM) used for prevention of osteoporosis and prophylaxis in women with risk factors for breast cancer
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Raloxifene
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Non-steroidal estrogen agonist causes clear cell adenocarcinoma of the vagina in daughters of women who used it during pregnancy
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Diethylstilbestrol (DES)
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2 Estrogens mostly used in oral contraceptives (OC)
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Ethinyl estradiol and mestranol
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Anti-progesterone used as abortifacient
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Mifepristone (RU-486)
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Constant low dose of estrogen and increasing dose of progestin for 21 days (last 5 days are sugar pills or iron prep)
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Combination oral contraceptives (OC)
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Oral contraceptive available in a transdermal patch
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Ortho-Evra
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Converted to more active form DHT by 5 alpha-reductase
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Testosterone
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5 alpha-reductase inhibitor used for benign prostatic hyperplasia (BPH) and male pattern baldness
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Finasteride (Proscar and Propecia respectively)
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Anabolic steroid that has potential for abuse
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Nandrolone, oxymetholone, and oxandrolone
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Anti-androgen used for hirsutism in females
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Cyproterone acetate
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Drug is used with testosterone for male fertility
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Leuprolide
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estrogen containing contraception increases risk of what?
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migraines
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use of large doses of anabolic steroids increases risk for what 2 disease processes?
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cholestatic jaundice and elevation of liver enzymes
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drug used to treat metastatic prostate CA
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flutamide
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drug used to treat endometriosis
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medroxyprogestrone to suppress ovulation
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finasteride prevents male patterned baldness by doing what?
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reducing production of DHT by inhibiting 5 alpha reductase
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why would you choose to treat low bone density with raloxifene instead of combo estrogen/medroxyprogesterone?
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positive family history of breast CA; it is antagonistic at breast and has no effects on endometrium
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name 3 SERMs
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tamoxifen, raloxifene, clomiphene
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SERM used to induce ovulation by blocking receptors in pituitary
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clomiphene
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clinical use and MOA of fulvestrant
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treat breast CA; antagonist at estrogen and progesterone receptors
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competitive inhibitor of aromatase
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anastrozole
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non-competitive inhibitor of aromatase
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exemestane
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MOA of leuprolide
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suppresses Gn secretion
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