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25 Cards in this Set
- Front
- Back
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3 zones of adrenal cortex and their products
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Glomerulosa (mineralocorticoids), fasciculata (glucocorticoid=GC), and reticularis (adrenal androgens)
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Pneumonic for 3 zones of adrenal cortex
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GFR
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Used for Addison's disease, Congenital Adrenal Hyperplasia (CAH), inflammation, allergies, and asthma (as a local inhalation)
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Glucocorticoids
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Short acting glucocorticoids
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Cortisone and hydrocortisone (equivalent to cortisol)
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Intermediate acting glucocorticoids
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Prednisone, methylprednisolone, prednisolone, and triamcinolone
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Long acting glucocorticoids
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Betamethasone and dexamethasone
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Mineralocorticoids
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Fludrocortisone and deoxycorticosterone
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Some side effects of corticosteroids
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Osteopenia, impaired wound healing, inc. risk of infection, inc. appetite, HTN, edema, PUD, euphoria, psychosis, stria, thinning of skin
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Period of time of therapy after which GC therapy will need to be tapered
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5-7 days
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Used to dx Cushing's syndrome (increased corticosteroid)
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Dexamethasone suppression test
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Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis
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Aminoglutethimide
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Antifungal agent used for inhibition of all gonadal and adrenal steroids
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Ketoconazole
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Antiprogestin used as potent antagonist of GC receptor
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Mifepristone
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Diuretic used to antagonize aldosterone receptors
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Spironolactone
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Common SE of spironolactone
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Gynecomastia and hyperkalemia
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pharmacologic effects of exogenous glucocorticoids include
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inhibition of leukotriene synthesis
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toxic effects of long term admin of glucocorticoid include
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osteoporosis
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what drug reduces the signs and sx of Cushing's syndrome due to adrenal tumor?
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Ketoconazole
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in treating CAH, admin of synthetic glucocorticoid is done to effect what outcome?
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suppression of ACTH secretion
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specific nucleotide sequence that is recognized by steroid hormone receptor-hormone complex
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response element
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what non-endocrine problem is treatable with glucocorticoids?
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chemo-induced vomiting
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why do you taper glucocorticoids?
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allow recovery of hypothalmic-pituitary-adrenal system
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a pt with acute adrenal insufficiency is likely to exhibit what sx?
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dehydration
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what combination of drugs is most effective in the tx of acute adrenal insufficiency?
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cortisol and fludrocortisone
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this drug blocks the glucocorticoid receptor
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mifepristone
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