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27 Cards in this Set
- Front
- Back
Vitamin K dependent anticoagulant
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Warfarin (PT)
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Warfarin is contraindicated in
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Pregnancy
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Anticoagulant of choice in pregnancy
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Heparin
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Heparin (PTT) increases activity of
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Antithrombin 3
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Route of administration of warfarin
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Oral
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Routes of administration of heparin
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IM (only LMW) and IV
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SE of both warfarin and heparin
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Bleeding
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SE of heparin
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Heparin induced thrombocytopenia (HIT)
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Alternative anticoagulant used if HIT develops
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Lepirudin
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Antidote to reverse actions of warfarin
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Vitamin K or fresh frozen plasma
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Antidote to reverse actions of heparin
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Protamine sulfate
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MOA of aspirin
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Irreversibly blocking cyclooxygenase
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Agent used to treat MI and to reduce incidence of subsequent MI
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Aspirin, metoprolol
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SE of Aspirin
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GI bleeding
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Antiplatelet drug reserved for patients allergic to aspirin
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Ticlopidine
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SE for ticlopidine
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Neutropenia and agranulocytosis
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Effective in preventing TIA's
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Clopidogrel and ticlopidine
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Prevents thrombosis in patients with artificial heart valve
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Dipyridamole
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Block glycoprotein IIb/IIIa involved in platelet cross-linking
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Abciximab, tirofiban and eptifibatide
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MOA of thrombolytics
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Degradation of fibrin clots and are administered IV
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Thrombolytics are used for
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Pulmonary embolism and DVT
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Thrombolytic that can cause allergic reaction
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Streptokinase
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Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA
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Tissue plasmin activator
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SE of tPA
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Cerebral hemorrhage
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Antidote used for heparin overdose
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Protamine
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Antidote used for warfarin toxicity
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Vitamin and Fresh frozen plasma (FFP)
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Antidote for tissue plasminogen activator (t-PA), streptokinase
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Aminocaproic acid
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