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21 Cards in this Set
- Front
- Back
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Prototypical drug is atropine
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Nonselective Muscarinic Antagonists
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Treat manifestations of Parkinson's disease and EPS
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Benztropine, trihexyphenidyl
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Treatment of motion sickness
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Scopolamine, meclizine
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Produce mydriasis and cycloplegia
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Atropine, homatropine,C1208 tropicamide
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Bronchodilation in asthma and COPD
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Ipratropium
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Reduce transient hyper GI motility
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Dicyclomine, methscopolamine
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Cystitis, postoperative bladder spasms, or incontinence
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Oxybutynin, dicyclomine
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Toxicity of anticholinergics
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block SLUD (salivation, lacrimation, urination, defecation
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Another pneumonic for anticholinergic toxicity
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"dry as a bone, red as a beet, mad as a hatter, hot as a hare, blind as a bat"
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Atropine fever is the most dangerous effect and can be lethal in this population group
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Infants
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Contraindications to use of atropine
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Infants, closed angle glaucoma, prostatic hypertrophy
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cardiac SE of atropine overdose
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increased HR
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cyclopentolate is an important drug for which part of the body?
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eye
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what sx would distinguish between an overdose of ganglion block vs muscarinic blocker?
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postural hypotension
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what drug has a high affinity for P atom in parathion and is used to treat insecticide toxicity?
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pralidoxime
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Limiting adverse effect of ganglion blockade that patients usually are unable to tolerate
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Severe hypertension
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Reversal of blockade by neuromuscular blockers
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Cholinesterase inhibitors
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Tubocurarine is the prototype, pancuronium, atracurium, vecuronium are newer short acting agent, produce competitive block at end plate nicotinic receptor, causing flaccid paralysis
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Nondepolarizing Neuromuscular Blockers
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Only member of depolarizing neuromuscular blocker, causes fasciculation during induction and muscle pain after use; has short duration of action
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Succinylcholine
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Chemical antagonists that bind to the inhibitor of ACh Estrace and displace the enzyme (if aging has not occurred)
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Cholinesterase regenerators, pralidoxime
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Used to treat patients exposed to insecticides such as parathion
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Pralidoxime, atropine
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