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18 Cards in this Set
- Front
- Back
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Atenolol
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Tx- angina, HTN (cheaply w/ diuretics)
-lowers HR/ contractility/ afterload -increase compliance (arterial) |
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HF beta-blocker
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Carvedilol
-late stage HF -feel worse for a long time then increase EF -start dry weight and work up |
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method of administration of nitrate vasodilators
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Nitroglycerin (topical)
Isosorbides (p.o.) -will only hit veins |
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anti-anginal with no change in afterload
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nitrates
will only hit veins |
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problems with nirtoglycerin
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100% hits heart
-immediate increase in CO may precipate angina -development of tolerance so you stagger the dose |
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must stagger the dose to prevent tolerance
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Nitroglycerin
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if you get a headache, it is working
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Nitroglycerin
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beware bronchocontriction
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atenolol, propanolol
beta-blockers -also acute exacerbation of HF |
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sudden withdrawl may precipate MI
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beta-blockers
atenolol propolol |
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anti-angina
decrease pletelet aggregation |
nitrates
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MOA nitrates
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NO donor---> venodilation
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Diltiazem
Verapamil MOA |
CCA blockers in heart
-lower HR/ Contractility/ TPR/ DBP -increase collateral flow |
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Amlodipine MOA
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CCA blocker in arterioles
-greater decrease DBP -reflex tachycardia -GERD -excessive vasodilation -paradoxical angina -pedal edema |
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grapefruit juice potentiates
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Amlodipine
(dihydropyridines) -lowers P450 |
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potentiates AV slowing w/ digoxin
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Verapamil
Diltiazem |
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cimetidine potentiated
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Diltiazem
lowers P450 |
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direct naturetic effect
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amlodipine
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will Tx angina w/o changing CO or TPR
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Amplodipine
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