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30 Cards in this Set

  • Front
  • Back
Quinidine
Class 1A antiarrythmic
*M, a-blk
Procainamide
Class 1A antiarrythmic
*M blk, more cardiosuppresant
Lidocaine
Class 1B antiarrythmic
*post-MI, open heart surgery, digitalis toxicity
Phenytoin
Class 1B antiarrythmic
*post-MI, open heart surgery, digitlis toxicity
Flecainide
Class 1C antiarrythmic
*limited use bec inc sudden death in post-MI & VT
Encainide
Class 1C antiarrythmic
*limited use bec inc sudden death in post-MI & VT
Propanolol
Class II Antiarrythmic: b-blkr
*prophylaxis post-MI, SVT
Acebutolol
Class II Antiarrythmic: b-blkr
*prophylaxis post-MI, SVT
Esmolol
Class II Antiarrythmic: b-blkr
*prophylaxis post-MI, SVT
Bretylium
Class III Antiarrythmic: K-blkr
*life-threatening vent arrhythmias
Amiodarone
Class III Antiarrythmic: K-blkr
*life-threatening vent arrhythmias
Verapamil
Class IV Antiarrhythmic: Ca-blkr
*SVT
Dilitiazem
Class IV Antiarrhythmic: Ca-blkr
*SVT
Adenosine
Antiarrhytmic
*PVST, AV nodal arrhythmia
Magnesium
Antiarrhythmic
*Torsades
Sotalol
Antiarrythmic
*2 enantiomers: dec K current, b-blker; for life-threatening ventricular arrhythmias
dec Vmax, blk fast Na chan
blk K chan
inc APD, ERP
Class IA antiarrhythmics
dec Vmac, blk fast Na chan
inc threshold, dec excitability
dec APD = inc diast, recovery
Class IB antiarrhythmics
lrg dec Vmax
blk fast Na chan, esp purkinje
Class IC antiarrhythmics
dec SA, AV nodal activity
dec slope 4
prev b1 activation
Class II: B-blockers
inc APD, ERP esp purkinje, vents
dec delayed K rectifier
= slows 3 (repol)
Class III: K chan blockers
dec SA, AV nodal activity
dec slope 4
Class IV: Ca chan blockers
Na chan opens: depolarization
Phase?
Phase 0
Na chan inactivated
Transient K out, Cl in = overshoot
Phase?
Phase 1
Slow Ca influx
Plateau
Phase?
Phase 2
Delayed K rectifier
Inactivation of time-dep Ca chan
Repolarization
Phase?
Phase 3
Return to resting membrane potential
Dependent on Na-K ATPase
Phase?
Phase 4
Inability to respond to stimulus
Effective Refractory Period (ERP)
Strong stimulus can elicit response
Relative Refractory Period (RRP)
PANS & SANS receptors in the heart
PANS: M2, slows/dec slope 4
SANS: B1, speeds/inc slope 4