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8 Cards in this Set
- Front
- Back
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Class IA
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Sodium channel blockers
-quinidine -Slow phase 0 and phase 3, lengthening action potential -Block rapidly firing cells more than normal ce -Bind open and inactivated Na+ channels, blocking Na+ flux |
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Class IB
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Sodium Channel Blockers
-lido -Shortens phase 3-decreases duration of AP -Blocks reentry |
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Class IC
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Sodium Channel Blockers
-Flecainide -Slowly dissociate from resting Na+ channels -Major phase 0 slowing -Used for refractory ventricular arrhythmias |
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Class II
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-Beta blockers
-Esmolol -Metoprolol -Propanolol -Prolong phase 4 |
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Class III
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K channel blockers
Amiodarone Sotalol -Block K+ channels -Prolong phase 3 |
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Class IV
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Calcium Channel Blockers
-diltazem -verapamil -Slow phase 4 depolarization -Slow AV node conduction -State dependent – bind to open, depolarized channels |
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Tx abnormal automaticity by...
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-Decreasing slope of phase 4
-Raise threshold of depolarization |
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Tx abnormalities in impulse conduction by...
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-Slowing conduction
-Increasing the refractory period |
