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21 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Imatinib mesylate
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BCL/Abl inhibitor
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kinase inhibitor that sits in ATP binding site for BCR/Abl (BCR/Abl prevents apoptosis) Chronic Myelogenous Leukemia
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Erlotinib
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Blocks RTK phosphorylation (EGFR tyrosine kinase inhibitor)
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RTK
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Trastuzumab
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Ab that Blocks RTK receptor
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RTK
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Sorafenib
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Blocks Raf in Ras pathway (inhibits multiple kinases including VEGFR=antiangiogenic)
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RTK
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Sirolimus (rapamycin)
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blocks mTOR of PIP3 pathway
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RTK
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Bevacizimab
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Antiangiogenic
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monoclonal anti-VEFG-Ab
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Gemcitabine
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Antimetabolites
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Only toxic in S phase; non-carcinogenic; similar to dCTP - stops DNA poly
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5-FU
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Antimetabolites
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Only toxic in S phase; non-carcinogenic; similar to dCTP - stops DNA poly
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Methotrexate
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Antimetabolites
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inhibits dihydrofolate reductase
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Cisplatin
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DNA crosslinking
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Pt agent
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Cyclophosphamide
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DNA crosslinking
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mustard gas like cisplatin
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Irinotecan
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Topoisomerase I poison
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topoisomerase I inhibitor.
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Topotecan
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Topoisomerase I poison
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Etoposide
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Topoisomerase II poison
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"Prevents DNA packaging/unpackaging caues Topo II to make ""nicks"" in DNA"
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Teniposide
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Topoisomerase II poison
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"Prevents DNA packaging/unpackaging caues Topo II to make ""nicks"" in DNA"
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Doxorubicin
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Topoisomerase II poison
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stablilize topo II adducts; forms free radicals; intercalation; inhibit helicase
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Daunorubicin
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Topoisomerase II poison
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stablilize topo II adducts; forms free radicals; intercalation; inhibit helicase
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Paclitaxel (taxol)
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Antimitotic
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prevents depoly
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Docetaxel (taxotere)
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Antimitotic
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Vincristine
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Antimitotic
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prevents elongation
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Vinblastine
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Antimitotic
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