Pharm Block C Antipsycotics And Movement Disorders

Front 1

haloperidol

Back 1

typical antipsycotic so strong D2 antagonist so increased risk for tardive dyskineasia and neuroleptic malignant syndrome

Front 2

-thixene

Back 2

typical antipsycotic so strong D2 antagonist so increase risk for tardive dyskinesia and NMS

Front 3

clozapine and side effect

Back 3

atypical antipsycotic blocks H1 mostly; used to prevent negative sx; agranulocytosis

Front 4

olanzipine

Back 4

atypical antipsycotic that blocks H1 mostly; no agranulocytosis as compared to clozapine

Front 5

risperidone

Back 5

atypical antipsycotic; 5HT-2A antagonist-prevents hallucinations

Front 6

zoprazidone

Back 6

atypical antipsycotic; blocks 5HT2A receptor; prevents hallucination

Front 7

aripiprazole

Back 7

atypical antipsycotic; partial D2 agonist (so acts like an antagonist partially as well); minimizes tardive dyskinesia and NMS sx

Front 8

palipepridone

Back 8

atypical antipsycotic; active metabolite of risperidone; inactivates mostly 5HT2A but also D2 like risperidone

Front 9

What type of antipsycotic, typical or atypical is containdicated at times? What 4 reasons are these times?

Back 9

typicals are contra in Parkinson's, liver dz, blood dyscrasias, and chronic alcohol abuse

Front 10

amantidine

Back 10

used early in Parkinson's; increases dopamine release from pre-synaptic vessicles

Front 11

dopamine and its limitations

Back 11

doesn't cross the BBB

Front 12

L-Dopa and adjunct

Back 12

used for early Parkinson's; crosses BBB; often given with carbidopa to prevent formation of dopamine peripherally which doesn't cross the BBB

Front 13

carbidopa

Back 13

used in early Parkinson's with L-Dopa; inhibits DOPA decarboxylase

Front 14

seligiline

Back 14

used in early Parkinson's when L-dopa and carbidopa combo fails; inhibits MAO-B in the pre-syn neuron so more dopamine is around to be released

Front 15

trihexylphenidryl and side effects

Back 15

used in EARLY Parkinson's or ALS; anti-muscarinic that acts everywhere; dry, hot, red, blind, mad

Front 16

benztropine

Back 16

used in early Parkinson's; anti-muscarinic that only acts centrally so you only get mad from it (not dry, red, hot, and blind hwvr)

Front 17

benzserazide

Back 17

used in early Parkinson's; prevents L-Dopa from conversion to dopamine peripherally; acts similarly to carbidopa

Front 18

-capone

Back 18

used in early Parkinson's; blocks COMT in the post-syn terminal; "think CAP one captures one COMeT"

Front 19

bromocryptine

Back 19

D2 agonist and PARTIAL D1 agonist used in late Parkinson's once the pre-syn neuron has been lost

Front 20

pergolide

Back 20

D2 agonist and PARTIAL D1 agonist used in late Parkinson's once the pre-syn neuron has been lost

Front 21

pramiprexole

Back 21

D2 agonist used in late Parkinson's; "think of a Ram using a rope to light D2 on fire"

Front 22

ropinirole

Back 22

D2 agonist used in late Parkinson's-distinguished from bromocryptine and pergolide because this has no PARTIAL D1 activity; "think of a Ram using a rope to light D2 on fire"

Front 23

diphenyhydramine

Back 23

adjunct in PD tx; primarily blocks H1 but also can block reuptake of DA

Front 24

ethopriopazine and its off label use

Back 24

anti-psychotic with anti-D2 activity; can be used for late PD because it also has anti-M activity

Front 25

procyclidine

Back 25

used in late PD; has atropine like effects so it decreases rigidity and reduces salivation (sialorrhea)

Front 26

siallorhea

Back 26

excess salivation

Front 27

Which PD drug can cause a hypertensive crisis?

Back 27

MAO-B inhibitor: seligiline

Front 28

What do high levels of B6 do to PD drug metabolism?

Back 28

B6 increases dopamine decarboxylase in the GI tract so that more L-Dopa is converted to dopamine and can't cross the BBB

Front 29

baclofen

Back 29

GABA-B agonist used in the palliative treatment of ALS to REDUCE SPASTICITY; GABA-B is inhibitory on NT release

Front 30

dicyclomine

Back 30

anti-muscarinic used in the palliative tx of ALS; used cosmetically really

Front 31

trihexyphenidyl

Back 31

anti-muscarinic used in the palliative tx of ALS OR PD; used cosmetically really

Front 32

oxyphencyclimine

Back 32

anti-muscarinic used in the palliative tx of ALS; used cosmetically really

Front 33

oxybutinin

Back 33

anti-muscarinic used in the palliative tx of ALS; used essentially to control urinary incontinence-block M receptor so can't contract bladder

Front 34

flavoxate

Back 34

anti-muscarinic used in the palliative tx of ALS; used to correct urinary incontinence-block M receptor so can't contract bladder

Front 35

Main tx for Huntington's?

Back 35

baclofen: activates GABA-B on the pre-syn neuron to hyperpolarize the neuron and inhibit NT release