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12 Cards in this Set
- Front
- Back
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What is the mechanism of levodopa (L-dopa)
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Metabolized to dopamine via dopa decarboxylase
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Which drug is metabolized to dopamine via dopa decarboxylase?
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levodopa
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What is levodopa (L-dopa) used to treat?
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Treats all symptoms of Parkinson's- do not start tx until patient shows debilitation.
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Which drug treats all symptoms of Parkinson's- do not start tx until patient shows debilitation?
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Levodopa (L-dopa)
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What is carbidopa used to treat?
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Treats Parkinson's with levodopa (L-dopa), minimizing levodopa's peripheral side effects
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Which drug treats Parkinson's with levodopa (L-dopa), minimizing levodopa's peripheral side effects
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levodopa (L-dopa)
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What is the mechanism of action of carbidopa
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L-AAAD inhibitor with no CNS penetrance
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Which drug is an L-AAAD inhibitor with no CNS penetrance
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Carbidopa
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What is entacapone used for?
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Co-administer with L-dopa to prolong the action of dopamine and increase L-DOPA access to the brain
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Which drug is co-administered with L-dopa to prolong the action of dopamine and increase L-DOPA access to the brain
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entacapone
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What is the mechanism of action of entacapone
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COMT inhibitor in the periphery. COMT metabolizes both dopamine and L-dopa so inhibition will increase L-DOPA access to the brain and prolong the action of dopamine
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Which drug is a COMT inhibitor in the periphery. COMT metabolizes both dopamine and L-dopa so inhibition will increase L-DOPA access to the brain and will prolong the action of dopamine
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entacapone
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