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72 Cards in this Set
- Front
- Back
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What drug is a PGE1 analog and could be used for abortion/ ulcer prevention in those who use NSAIDS chroincally
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Misoprostol
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Misoprostol works on what receptor in what way?
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PGE1 analog
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What is misoprostol used for
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Ulcer prevention caused by chronic NSAID use
Abortion if combined with mifeprisone or methotrexate |
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What is a drug that is a PGE1 analog and could be used for impotence treatment/maintaining a PDA
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Alprostadil
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What receptor does Dinoprostone work on?
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PGE2 analog.
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What effects does Dinoprostone have?
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Facilitates labor (cervical ripening, uterine contractions)
2) Abortion |
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What does Epoprostenol work on?
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PGI2 analog
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What is epoprostenol used for
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treat primary pulmonary hypertension
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What is a PGE2 analog used to stimulate childbirth/ used in abortion
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Dinoprostone
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What is a PGI2 analog used to treat primary pulmonary hypertension
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Epoprostenol
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What does bimatoprost work on?
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PGF2alpha analog
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What is bimatoprost used to treat
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Glaucoma
Eyelash hypotrichosis |
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What is a PGF2alpha analog used to treat glaucoma and hypotrichosis
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Bimatoprost
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What is alprostadil used for?
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Treat ED
Maintain PDA |
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What receptor does Alprostadil work on
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PGE1 analog
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How does Cromolyn Sodium work?
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Histamine inhibitor - stabilizes mast cell membrane
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How does omalizumab work?
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Histamine inhibitor - decreases amount of IgE that binds to and sensitizes mast cells.
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What is cromolyn sodium used in
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Preventative management of asthma
Allergic rhinitis, conjunctivitis (food allergies?) |
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What is omalizumab used in
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Allergic asthma
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What is a drug that is used in preventative management of asthma along with allergic rhinitis and conjunctivitis that works on stabilizing mast cell membranes to inhibit histamine?
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Cromolyn sodium
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What is a drug that inhibits histimine by decreasing amount of antigen specific IgE that binds mast cells and in turn treats allergic asthma
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Omalizumab
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What are the first generation H1 receptor blockers
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Diphenhydramine
Dimenhydrinate Chlorpheniramine Promethazine |
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Do first generation H1 receptor blockers have anti-cholinergic effects? Are they sedating
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Yes first generation H1 receptor blockers have anti cholinergic effects. Yes first generation H1 blockers are sedating.
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What is diphenhydramine used in
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Acute allergies
Motion sickness Insomnia early stage parkinsons |
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What is dimenhydrinate used in?
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Motion sickness, vestibular disturbances
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What is chlorpheniramine used in?
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Acute allergies
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What is promethazine used in?
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Motion sickness, chemotherapy induced nausea, vomiting
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What is a first generation H1 blocker you could give to treat acute allergies, motion sickness, insomnia, or parkinsons?
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diphenhydramine
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What is a first generation H1 blocker you could give to treat motion sickness and vestibular disorders
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dimenhydrinate
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What is a first generation H1 blocker you could give to treat only acute allergies
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chlorpheniramine
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What is a first generation H1 blocker you could give to treat motion sickness and chemotherapy induced vomiting
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promethazine
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What are the second generation H1 receptor blockers
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Fexofenadine
Loratadine Desloratadine Cetirizine (higher incidence of sedation compared to the others) |
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Are the second generation H1 receptor blockers sedating? Do the second generation H1 receptor blockers give anti cholinergic effects?
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No, the second generation H1 blockers are non sedating. The H1 blockers do not give anti cholinergic effects
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What is fexofenadine?
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fexofenadine is a 2nd generation h1 blocker used to treat acute allergies
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What is loratadine?
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loratadine is a 2nd generation h1 blocker used to treat acute allergies
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What is desloratadine?
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desloratadine is a 2nd generation h1 blocker used to treat acute allergies
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What is cetirizine?
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cetirizine is a 2nd generation h1 blocker used to treat acute allergies. it has a higher rate of sedation compared to the second generation drugs.
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What are the H2 receptor blockers?
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Famotidine
Ranitidine Cimetidine |
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What is the order of the H2 receptor blockers from most potent to least potent
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Famotidine
Ranitidine Cimetidine |
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What is famotidine
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Famotidine is the most potent H2 receptor blocker used to treat GERD, promote gastric and duodenal ulcer healing, and prevent stress ulcers.
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What is Ranitidine
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Ranitidine is a drug used to treat GERD, promote gastric duodenal ulcers healing, and prevent stress ulcers. It is an intermediate strength H2 blocker.
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What is Cimitidine
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Cimitidine is the least potent H2 receptor blocker (inhibits CYP3A4 cytochromes) used in treating GERD, promote gastric and duodenal ulcers healing and preventing stress ulcers.
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What H2 blocker could I give if I wanted to give the most potent one? What could it treat?
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Famotidine. H2 blockers treat GERD, promote gastric and duodenal ulcer healing, and preventing stress ulcers.
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What intermediate H2 blocker exists? What could it treat?
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Ranitidine is the intermediate strength H2 blocker. It is used to treat GERD, promote healing of gastric and duodenal ulcers, and prevent stress ulcers.
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What are the adrenal steroid drugs to know?
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Cortisol, Prednisolone, Dexamethasone, Fludrocortisone, Aldosterone
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What are the anti-inflammatory potency and sodium retention of cortisol
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1 and 1. They are based off cortisol
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What are the anti-inflammatory potency and sodium retention of prednisolone?
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Anti-inflammatory -2.5
Sodium retention - 0.8 |
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What are the anti-inflammatory potency and sodium retention of dexamethasone?
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Anti-inflammatory - 20
Sodium retention- 0 |
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What are the anti-inflammatory potency and sodium retention of fludrocortisone?
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Anti-inflammatory 12
Sodium retention 100 |
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What are the anti-inflammatory potency and sodium retention of aldosterone
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Antiinflamm - 0.2
Sodium retention 250 |
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What effects do adrenal steroids have?
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all roads in ohio are congested smelly messes
a- adrenal insufficiency - steroid replacement therapy r- rheumatoid arthritis i- inflammatory diseases of eyes, ear, skin o- osteoarthritis a- allergic diseases (hay fever, drug reaction, bronchial asthma) c- cerebral edema s - shock (questionable value) m- miscelaneous ( organ transplant, thrombocytopenia, liver diseases, collagen diseases etc.) |
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What are the adrenal steroid drugs?
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Cortisol
Prednisolone Dexamethasone Fludrocortisone Aldosterone |
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What drug has anti-inflammatory value of 1; sodium retention value of 1
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Cortisol
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What drug has anti-inflammatory value of 2.5; sodium retention value of 0.8
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Prednisolone
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What drug has anti-inflammatory value of 20, sodium retention value of 0?
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Dexamethasone
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What drug has anti-inflammatory value of 12, sodium retention value of 100
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Fludrocortisone
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What drug has anti-inflammatory value of 0.2, sodium retention value of 250
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Aldosterone
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What does metyrapone do?
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Blocks 11-B hydroxylation
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What drug blocks 11-B- hydroxylation
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Metyrapone
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How is metyrapone used in a diagnostic test?
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Used to test adrenal insufficiency- instead of synthesizing cortisol, you get synthesis stopped at 11-desoxycortisol. This does not inhibit ACTH release, so ACTH rises. ACTH stimulates synthesis and excretion of 17-hydroxycorticoids. (check the urine- if high levels, normal).
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What is mifepristones MOA
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Blocks Progesterone and glucocorticoid receptor
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What to use mifepristone therapeutically for?
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1. Pregnancy termination
2. Cushing's Disease |
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What drug could you give that blocks both the progesterone and glucocorticoid receptor?
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Mifepristone
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What drug could you get that terminates pregnancy and is used in cushings
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Mifepristone
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Spironolactone and Eplerenone MOA?
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Block mineralocorticoid receptor
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What are therapeutic uses of Spironolactone and eplerenone?
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1. Diueretics/ treat HTN
2. Cardiac hypertrophy and heart failure |
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What drugs could you give that blocks the mineralocorticoid receptor?
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Eplerenone and spironolactone
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What drug has a diuretic effect to treat HTN and also can be used in HF/cardiac hypertrophy?
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Spironolactone and eplerenone
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What is drospirenone's mechanism of action?
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Progesterone receptor agonist
Mineralocorticoid and android receptor antagonist. |
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What is drospirenone's use?
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Supress ovulation; hormone replacement in post menopausal women
Diueretic- antagonizes salt retaining estrogen |
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What drug can supress ovulation/serve as hormonal replacement in post menopausal women as well as serve as diuretic that opposes that salt retaining effects of estrogen?
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Drospirenone
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What drug is an antagonist to androgen receptor and mineralocorticoid receptor but an agonist to progesterone
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Drospirenone
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