Pharm: Autacoids Quick Review

Front 1

Histamine

Back 1

Histamine Agonist
H1: NO formation
H2: stimulates gastric acid secretion

Front 2

Epinephrine

Back 2

Histamine Antagonist (physiological)
Uses: Anaphylactic shock

Front 3

Cromolyn

Back 3

Histamine Antagnonist (release inhibitors)
Uses: Asthma

Front 4

Nedocromil

Back 4

Histamine Antagnonist (release inhibitors)
Uses: Asthma

Front 5

Chlorpheniramine

Back 5

H1 blockers (1st Gen)
allergic conditions, motion sickness/nausea, somnifacients
sedative effects

Front 6

Dimenhydrinate

Back 6

H1 blockers (1st Gen)
allergic conditions, motion sickness/nausea, somnifacients
sedative effects

Front 7

Diphenhydramine

Back 7

H1 blockers (1st Gen)
allergic conditions, motion sickness/nausea, somnifacients
sedative effects

Front 8

Doxylamine

Back 8

H1 blockers (1st Gen)
allergic conditions, motion sickness/nausea, somnifacients
sedative effects

Front 9

Hydroxyzine

Back 9

H1 blockers (1st Gen)
allergic conditions, motion sickness/nausea, somnifacients
sedative effects

Front 10

Meclizine

Back 10

H1 blockers (1st Gen)
allergic conditions, motion sickness/nausea, somnifacients
sedative effects

Front 11

Promethazine

Back 11

H1 blockers (1st Gen)
allergic conditions, motion sickness/nausea, somnifacients
sedative effects

Front 12

Astemizole

Back 12

H1 blockers (2nd Gen)
allergic conditions, motion sickness/nausea, somnifacients
less sedating
-fatal arrhythmias when combined w/ erythromycin/grape fruit juice

Front 13

Fexofenadine

Back 13

H1 blockers (2nd Gen)
allergic conditions, motion sickness/nausea, somnifacients
less sedating

Front 14

Terfenadine

Back 14

H1 blockers (2nd Gen)
allergic conditions, motion sickness/nausea, somnifacients
less sedating
-fatal arrhythmias when combined w/ erythromycin/grape fruit juice

Front 15

Loratadine

Back 15

H1 blockers (2nd Gen)
allergic conditions, motion sickness/nausea, somnifacients
less sedating

Front 16

Cetirizine

Back 16

H1 blockers (2nd Gen)
allergic conditions, motion sickness/nausea, somnifacients
less sedating

Front 17

Acrivastine

Back 17

H1 blockers (2nd Gen)
allergic conditions, motion sickness/nausea, somnifacients
less sedating

Front 18

Cimetidine

Back 18

H2 blockers
peptic ulcers, acute stress ulcers, GERD

Front 19

Ranitidine

Back 19

H2 blockers
peptic ulcers, acute stress ulcers, GERD

Front 20

Famotidine

Back 20

H2 blockers
peptic ulcers, acute stress ulcers, GERD

Front 21

Nizatidine

Back 21

H2 blockers
peptic ulcers, acute stress ulcers, GERD

Front 22

Serotonin

Back 22

Serotonin Receptor Agonist
increase GI motility, increase ACh, vasoconstriction on vascular SM, platelet aggregation

Front 23

Sumatriptan

Back 23

Serotonin Receptor Agonist
5-HT1D/B agonist
1st line for acute severe migraines

Front 24

Metoclopramide

Back 24

Serotonin Receptor Agonist
5-HT4 agonist
for lazy GIT

Front 25

Cisapride

Back 25

Serotonin Receptor Agonist
5-HT4 agonist
for lazy GIT (not avail in US due to heart effects)

Front 26

Cyproheptadine

Back 26

Serotonin Receptor Antagonist
5-HT2 blocker
allergic/vasomotor rhinitis, cold urticaria, dermatographism, carcinoid tumor, serotonin syndrome
-potent H1 blocking action

Front 27

Ondasetron

Back 27

Serotonin Receptor Antagonist
5-HT3 blocker
anti-emtic cancer chemotherapy

Front 28

Granisetron

Back 28

Serotonin Receptor Antagonist
5-HT3 blocker
anti-emtic cancer chemotherapy

Front 29

Ergotamine

Back 29

Affect a-adrenoreceptors, D & 5-HT R
migraine

Front 30

Dihydroergotamine

Back 30

Affect a-adrenoreceptors, D & 5-HT R
migraine

Front 31

Bromocriptine

Back 31

Affect a-adrenoreceptors, D & 5-HT R
hyperprolactinemia

Front 32

Cabergoline

Back 32

Affect a-adrenoreceptors, D & 5-HT R
hyperprolactinemia

Front 33

Methylergonovine

Back 33

Affect a-adrenoreceptors, D & 5-HT R
Postpartum hemorrhage IM

Front 34

Ergonovine

Back 34

Affect a-adrenoreceptors, D & 5-HT R
Dx of variant angina

Front 35

Dinoprostone

Back 35

Eicosanoids
PGE2
ripen cervix at term before induction of labor, abortifacient

Front 36

Carboprost

Back 36

Eicosanoids
PGE2 & 15 methyl-PGF2a
abortifacient

Front 37

Tromethamine

Back 37

Eicosanoids
PGE2 & 15 methyl-PGF2a
abortifacient

Front 38

Misoprostol

Back 38

Eicosanoids
PGE1
abortifacient used w/ mifepristone or methotrexate
prevention of peptic ulcers in NSAID users

Front 39

Alprostadil

Back 39

Eicosanoids
PGE1
patency of ductus arteriosus

Front 40

Prostacyclin

Back 40

Eicosanoids
PGI2
Pulmonary HTN, dialysis: prevents platelet aggregation

Front 41

Latanoprost

Back 41

Eicosanoids
PGF2a
Glaucoma

Front 42

Bimatoprost

Back 42

Eicosanoids
PGF2a
Glaucoma

Front 43

Travoprost

Back 43

Eicosanoids
PGF2a
Glaucoma

Front 44

Unoprostone

Back 44

Eicosanoids
PGF2a
Glaucoma

Front 45

Zileuton

Back 45

Eicosanoid Antagonist
LT pathway inhibitor (inhibits 5-lipoxygenase)
-Asthma

Front 46

Zafirlukast

Back 46

Eicosanoid Antagonist
LT pathway inhibitor (inhibits binding of LTD4 to its receptor in target)

Front 47

Montelukast

Back 47

Eicosanoid Antagonist
LT pathway inhibitor (inhibits binding of LTD4 to its receptor in target)

Front 48

Corticosteroids

Back 48

Eicosanoid Antagonist
inhibit prod. of arachidonic acid and COX-2
-anti-inflammatory

Front 49

NSAIDs

Back 49

Eicosanoid Antagonist
inhibit cyclo-oxgenases, COX-1 and COX-2
-anti-inflammatory, analgesic, antipyretic