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39 Cards in this Set

  • Front
  • Back
what are the prototypical anxiolytic drugs?
Clordiazepoxide
Diazepam
What is the MOA of BZDs?
Potentiates GABA
Blocks the RAS-leads to sedation and ataxia
How do you treat a BZD overdose?
Flumazenil: 0.5mg IV once
What is the DOC for panic disorders?
Paxil-SSRI
where is 70% of CNS norepi found?
Locus Cerulus
What is the DOC to treat GAD
BZDs
what is the most used BZD for prophylaxis against seizures?(esp in children)
Klonopin
What are the side effects of BZDs
Drowsiness
Addiction
memory impairment
How do you treat GAD?
Non-pharm: Behavioral changes, supportive groups

DOC: BZDs and Buspar(non-addictive)
Which BZD would you use for alcohol withdrawl symptoms?
Librium
which are the injectable BZDs
Diazepam(valium)faster acting (better for surgical procedures)

Lorazepam (ativan)slower
what are the BZD equivalent dosing?
Xanax 0.5mg
Lorazepam 1mg
Valium 5mg
Tranxene 7.5mg
Chlordiazepoxide 10mg PO only
what's the BZD DOC in an icu setting?
Lorazepam, unless patient has muscle spasms, then give Diazepam
which BZDs are safe for elderly?
LOT

Lorazepam-for anxiety
Oxazepam
Temazepam-for sleep
which drug does NOT have addictive properties
Buspar
What is the MOA of Buspar
5HT partial agonist
Has no anticonvulsive properties or muscle relaxation
What is the onset of Buspar
2-4 weeks
What is the dose of Buspar
15mg PO TID
what should you NEVER mix MAOIs with?
drugs that affect serotonin; causes serotonin syndrome
How do you treat Panic disorders
TCA- Desipramine,Imipramine
MAOI-may take longer to act
BZD- use a rapid(diazepam)
SSRI
what's the definition of Panic disorder
At least 4 attacks within a 4 week period; one attack "out of the blue"
Which drugs should you NOT use in the elderly?
Drugs with active metabolites:

Flurazepam (BZD)
What kind of drug is Flurazepam (Dalmane)
BZD- long acting hypnotic
Has active metabolite
What is Temazepam (restoril)
BZD hypnotic
No active metabolites (safe with elderly)
Name a Non-BZD hypnotic
Zolpidem (ambien)
which drug is used for eating disorders?
Prozac
drug for OCD
LuVox
What drug is approved for premenstrual disorder
Fluoxetine
What drug is approved for Major depressive disorder
Venlafaxine
Celexa is only approved for what disorder
Major Depressive disorder
What is a side effect of Effexor?
may cause HTN because the drug affects norepi; therefore do NOT rx to hypertensive pts
Which SSRIs are 3A4 metabolized?
Zoloft
Celexa
Lexapro

All others are 2D6
what are the drug interactions for fluoxetine (prozac)
MAOI
NSAIDS
Thioridazine
Warfarin
BZDs
Carbamazepine
Phenytoin
what are the drug interactions for paxil
MAOI
NSAIDS
Thioridazine
Warfarin
Tryptophan
what's the dose of Fluoxetine(Prozac)
20mg daily
what is the dose for Paroxetine(Paxil)
20mg daily
what is the dose for Venlafaxine (effexor) ER?
150mg QD

if side effects: split to 75mg TID
What are the equivalent doses for the BZDs
Xanax 0.5mg
Lorazepam 0.1mg
Diazepam 5,g
Chlorazepate 7.5mg
Chlordiazepoxide 10mg PO
Which BZDs do NOT have active metabolites?
Lorazepam(Ativan)
Oxazepam(Serax)
Temazepam(Restoril)