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39 Cards in this Set
- Front
- Back
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what are the prototypical anxiolytic drugs?
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Clordiazepoxide
Diazepam |
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What is the MOA of BZDs?
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Potentiates GABA
Blocks the RAS-leads to sedation and ataxia |
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How do you treat a BZD overdose?
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Flumazenil: 0.5mg IV once
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What is the DOC for panic disorders?
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Paxil-SSRI
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where is 70% of CNS norepi found?
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Locus Cerulus
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What is the DOC to treat GAD
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BZDs
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what is the most used BZD for prophylaxis against seizures?(esp in children)
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Klonopin
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What are the side effects of BZDs
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Drowsiness
Addiction memory impairment |
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How do you treat GAD?
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Non-pharm: Behavioral changes, supportive groups
DOC: BZDs and Buspar(non-addictive) |
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Which BZD would you use for alcohol withdrawl symptoms?
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Librium
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which are the injectable BZDs
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Diazepam(valium)faster acting (better for surgical procedures)
Lorazepam (ativan)slower |
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what are the BZD equivalent dosing?
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Xanax 0.5mg
Lorazepam 1mg Valium 5mg Tranxene 7.5mg Chlordiazepoxide 10mg PO only |
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what's the BZD DOC in an icu setting?
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Lorazepam, unless patient has muscle spasms, then give Diazepam
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which BZDs are safe for elderly?
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LOT
Lorazepam-for anxiety Oxazepam Temazepam-for sleep |
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which drug does NOT have addictive properties
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Buspar
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What is the MOA of Buspar
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5HT partial agonist
Has no anticonvulsive properties or muscle relaxation |
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What is the onset of Buspar
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2-4 weeks
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What is the dose of Buspar
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15mg PO TID
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what should you NEVER mix MAOIs with?
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drugs that affect serotonin; causes serotonin syndrome
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How do you treat Panic disorders
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TCA- Desipramine,Imipramine
MAOI-may take longer to act BZD- use a rapid(diazepam) SSRI |
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what's the definition of Panic disorder
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At least 4 attacks within a 4 week period; one attack "out of the blue"
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Which drugs should you NOT use in the elderly?
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Drugs with active metabolites:
Flurazepam (BZD) |
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What kind of drug is Flurazepam (Dalmane)
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BZD- long acting hypnotic
Has active metabolite |
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What is Temazepam (restoril)
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BZD hypnotic
No active metabolites (safe with elderly) |
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Name a Non-BZD hypnotic
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Zolpidem (ambien)
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which drug is used for eating disorders?
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Prozac
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drug for OCD
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LuVox
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What drug is approved for premenstrual disorder
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Fluoxetine
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What drug is approved for Major depressive disorder
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Venlafaxine
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Celexa is only approved for what disorder
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Major Depressive disorder
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What is a side effect of Effexor?
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may cause HTN because the drug affects norepi; therefore do NOT rx to hypertensive pts
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Which SSRIs are 3A4 metabolized?
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Zoloft
Celexa Lexapro All others are 2D6 |
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what are the drug interactions for fluoxetine (prozac)
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MAOI
NSAIDS Thioridazine Warfarin BZDs Carbamazepine Phenytoin |
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what are the drug interactions for paxil
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MAOI
NSAIDS Thioridazine Warfarin Tryptophan |
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what's the dose of Fluoxetine(Prozac)
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20mg daily
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what is the dose for Paroxetine(Paxil)
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20mg daily
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what is the dose for Venlafaxine (effexor) ER?
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150mg QD
if side effects: split to 75mg TID |
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What are the equivalent doses for the BZDs
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Xanax 0.5mg
Lorazepam 0.1mg Diazepam 5,g Chlorazepate 7.5mg Chlordiazepoxide 10mg PO |
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Which BZDs do NOT have active metabolites?
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Lorazepam(Ativan)
Oxazepam(Serax) Temazepam(Restoril) |
